Detailed information of TA system TA208914

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 557337..557973
• Replicon: chromosome
• Accession: NZ_CP078027
• Organism: Acinetobacter variabilis strain AV_175

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EGK58_RS02580
• Protein ID: WP_125278961.1
• Coordinates: 557587..557973 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: EGK58_RS02575
• Protein ID: WP_125278962.1
• Coordinates: 557337..557594 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGK58_RS02555 (EGK58_002555)	552838..553845	+	1008	WP_004786889.1	DNA-directed RNA polymerase subunit alpha	-
EGK58_RS02560 (EGK58_002560)	553864..554229	+	366	WP_004786886.1	50S ribosomal protein L17	-
EGK58_RS02565 (EGK58_002565)	554438..555928	+	1491	WP_125278964.1	NAD(P)/FAD-dependent oxidoreductase	-
EGK58_RS02570 (EGK58_002570)	555982..557154	-	1173	WP_125278963.1	acyl-CoA dehydrogenase family protein	-
EGK58_RS02575 (EGK58_002575)	557337..557594	+	258	WP_125278962.1	succinate dehydrogenase assembly factor 2	Antitoxin
EGK58_RS02580 (EGK58_002580)	557587..557973	+	387	WP_125278961.1	hypothetical protein	Toxin
EGK58_RS02585 (EGK58_002585)	558520..559560	+	1041	WP_125278960.1	hypothetical protein	-
EGK58_RS02590 (EGK58_002590)	559633..560205	+	573	WP_125278959.1	rhombosortase	-
EGK58_RS02595 (EGK58_002595)	560383..562665	+	2283	WP_125278958.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15246.42 Da
• Isoelectric Point: 10.0581

>T208914 WP_125278961.1 NZ_CP078027:557587-557973 [Acinetobacter variabilis]
MDNRCFRLKRSKCALVFQLFIFAVLMFLLYQLLPVIMWLVCGVIGLVIYQLFYRKIPHIEQFEYLDGREWSLTAAAQGTR
RVLISHVIDHQAYIVVYFQHAKARPLLIWCDQLPFKQWKSLKVLTKIL

Nucleotide

• Length: 387 bp

>T208914 NZ_CP103755:c4769116-4768943 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10309.80 Da
• Isoelectric Point: 4.4709

>AT208914 WP_125278962.1 NZ_CP078027:557337-557594 [Acinetobacter variabilis]
MTDDITLEERKVIYRARRGLKEIDVYFDPYVKNYYLNADPFEKEMFAELVAQEDPDLLDWFMEVSEPPRPELKDFIKKLK
FYVHG

Nucleotide

• Length: 258 bp

>AT208914 NZ_CP103755:c4769440-4769144 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG