Detailed information of TA system TA208907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 3187773..3188381
• Replicon: chromosome
• Accession: NZ_CP078017
• Organism: Alcaligenes aquatilis strain 393

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EGK70_RS14780
• Protein ID: WP_094197431.1
• Coordinates: 3187773..3188063 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: EGK70_RS14785
• Protein ID: WP_094197432.1
• Coordinates: 3188076..3188381 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGK70_RS14760 (EGK70_014760)	3183049..3183636	-	588	WP_094197428.1	XRE family transcriptional regulator	-
EGK70_RS14765 (EGK70_014765)	3183776..3184738	+	963	WP_094198411.1	ornithine cyclodeaminase family protein	-
EGK70_RS14770 (EGK70_014770)	3184775..3186067	+	1293	WP_094197429.1	MFS transporter	-
EGK70_RS14775 (EGK70_014775)	3186335..3187723	+	1389	WP_164461461.1	ATP-dependent RNA helicase DbpA	-
EGK70_RS14780 (EGK70_014780)	3187773..3188063	+	291	WP_094197431.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGK70_RS14785 (EGK70_014785)	3188076..3188381	+	306	WP_094197432.1	putative addiction module antidote protein	Antitoxin
EGK70_RS14790 (EGK70_014790)	3188471..3189427	-	957	WP_108727827.1	LysR substrate-binding domain-containing protein	-
EGK70_RS14795 (EGK70_014795)	3189812..3191170	+	1359	WP_094197434.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
EGK70_RS14800 (EGK70_014800)	3191167..3191715	+	549	WP_094197435.1	3-phenylpropionate/cinnamic acid dioxygenase subunit beta	-
EGK70_RS14805 (EGK70_014805)	3191744..3192064	+	321	WP_094198412.1	bifunctional 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit	-
EGK70_RS14810 (EGK70_014810)	3192061..3192876	+	816	WP_094197436.1	3-(cis-5,6-dihydroxycyclohexa-1, 3-dien-1-yl)propanoate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (5-93)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10969.39 Da
• Isoelectric Point: 7.2772

>T208907 WP_094197431.1 NZ_CP078017:3187773-3188063 [Alcaligenes aquatilis]
MKTIHTTDTFDHWFSGLRDKQAARRIQVRIDRAEDGNFGDCESVGEGVSEMRIHYGPGYRVYFVQRELEIVILLAGGNKS
TQNKDIKTALEIARQL

Nucleotide

• Length: 291 bp

>T208907 NZ_CP103755:3803852-3804070 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10913.57 Da
• Isoelectric Point: 6.7173

>AT208907 WP_094197432.1 NZ_CP078017:3188076-3188381 [Alcaligenes aquatilis]
MGTIKLRKWDSAEHLQTEEDMVLYLEACMEEAGNDAAFIAKALGNIARAKGMSQLAKETGLGRESLYKALSGEGNPSFGT
ILKVMHALGIKLQPQLAPHNS

Nucleotide

• Length: 306 bp

>AT208907 NZ_CP103755:3803452-3803826 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG