Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1456373..1456968 Replicon chromosome
Accession NZ_CP078017
Organism Alcaligenes aquatilis strain 393

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EGK70_RS06630 Protein ID WP_123051553.1
Coordinates 1456663..1456968 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EGK70_RS06625 Protein ID WP_125277630.1
Coordinates 1456373..1456666 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGK70_RS06600 (EGK70_006600) 1451992..1452303 - 312 WP_219003604.1 hypothetical protein -
EGK70_RS06605 (EGK70_006605) 1452540..1452812 - 273 WP_094196159.1 hypothetical protein -
EGK70_RS06610 (EGK70_006610) 1453000..1454403 - 1404 WP_108727163.1 GntP family permease -
EGK70_RS06620 (EGK70_006620) 1455252..1456118 + 867 WP_208393584.1 hypothetical protein -
EGK70_RS06625 (EGK70_006625) 1456373..1456666 - 294 WP_125277630.1 putative addiction module antidote protein Antitoxin
EGK70_RS06630 (EGK70_006630) 1456663..1456968 - 306 WP_123051553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGK70_RS06635 (EGK70_006635) 1457488..1458864 + 1377 WP_166727071.1 FAD-dependent oxidoreductase -
EGK70_RS06640 (EGK70_006640) 1459123..1459698 + 576 WP_108727216.1 TetR/AcrR family transcriptional regulator -
EGK70_RS19665 1459786..1459887 + 102 Protein_1295 hypothetical protein -
EGK70_RS06650 (EGK70_006650) 1459926..1460630 - 705 WP_125277628.1 SDR family oxidoreductase -
EGK70_RS06655 (EGK70_006655) 1460734..1461606 + 873 WP_125277627.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-88)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11485.21 Da        Isoelectric Point: 10.2587

>T208905 WP_123051553.1 NZ_CP078017:c1456968-1456663 [Alcaligenes aquatilis]
MNTINRSETFSTWLTGLKDLKARAKIVVRIKQASLGNFGDVKPISDGVYEMRIHFGPGYRLYYAREGRVVYLLLSGGDKS
SQKQDIKTAIAMWKQIQEDQS

Download         Length: 306 bp

>T208905 NZ_CP103755:2923314-2923421 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10310.87 Da        Isoelectric Point: 4.8359

>AT208905 WP_125277630.1 NZ_CP078017:c1456666-1456373 [Alcaligenes aquatilis]
MTTLKTAPFDAAEYLDSEEAIAEYLSAALEEDDPALFLSALADVVKARGMTKMAKDAGVGRESLYKALAPGAKPRYDTVL
KLARAAGVKLTVEPIHA

Download         Length: 294 bp

>AT208905 NZ_CP103755:c2923257-2923202 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References