Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907(toxin) |
| Location | 29562..30133 | Replicon | plasmid pSY-1-optrA |
| Accession | NZ_CP078016 | ||
| Organism | Enterococcus faecalis strain SY-1 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | A0A2Z2CGM4 |
| Locus tag | KUO14_RS14235 | Protein ID | WP_002362432.1 |
| Coordinates | 29562..29903 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | R3KHK9 |
| Locus tag | KUO14_RS14240 | Protein ID | WP_002362431.1 |
| Coordinates | 29903..30133 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KUO14_RS14205 (24987) | 24987..25349 | + | 363 | WP_024378353.1 | EFR1 family ferrodoxin | - |
| KUO14_RS14210 (25474) | 25474..26205 | - | 732 | WP_002360844.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| KUO14_RS14215 (26465) | 26465..27145 | + | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| KUO14_RS14220 (27252) | 27252..27506 | - | 255 | WP_010711045.1 | transposase | - |
| KUO14_RS14225 (27645) | 27645..28247 | - | 603 | WP_002362434.1 | Fic family protein | - |
| KUO14_RS14230 (28512) | 28512..29450 | - | 939 | WP_002362433.1 | hypothetical protein | - |
| KUO14_RS14235 (29562) | 29562..29903 | - | 342 | WP_002362432.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| KUO14_RS14240 (29903) | 29903..30133 | - | 231 | WP_002362431.1 | hypothetical protein | Antitoxin |
| KUO14_RS14245 (30337) | 30337..30957 | + | 621 | WP_013438829.1 | recombinase family protein | - |
| KUO14_RS14250 (30974) | 30974..31258 | + | 285 | WP_002394798.1 | hypothetical protein | - |
| KUO14_RS14255 (31260) | 31260..31493 | + | 234 | WP_002394799.1 | hypothetical protein | - |
| KUO14_RS14260 (31653) | 31653..31907 | - | 255 | WP_002394800.1 | hypothetical protein | - |
| KUO14_RS14265 (32024) | 32024..32692 | - | 669 | WP_002403283.1 | CPBP family intramembrane metalloprotease | - |
| KUO14_RS14270 (32728) | 32728..33045 | - | 318 | WP_002394802.1 | heavy metal-binding domain-containing protein | - |
| KUO14_RS14275 (33540) | 33540..33650 | + | 111 | WP_002360667.1 | type I toxin-antitoxin system Fst family toxin | - |
| - (33690) | 33690..33781 | - | 92 | NuclAT_0 | - | - |
| - (33690) | 33690..33781 | - | 92 | NuclAT_0 | - | - |
| - (33690) | 33690..33781 | - | 92 | NuclAT_0 | - | - |
| - (33690) | 33690..33781 | - | 92 | NuclAT_0 | - | - |
| KUO14_RS14280 (33890) | 33890..34186 | + | 297 | WP_002403282.1 | hypothetical protein | - |
| KUO14_RS14285 (34345) | 34345..34686 | - | 342 | WP_002382053.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | erm(B) / aph(3')-III / dfrG / fexA / optrA / erm(A) | - | 1..35987 | 35987 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13244.44 Da Isoelectric Point: 8.0113
>T208900 WP_002362432.1 NZ_CP078016:c29903-29562 [Enterococcus faecalis]
MSDEKKYIPKKGDIVWIDFDPSAEKEIQKRRPGLVVSRYEFNRKTLFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFAERKLSQIEHLPLKDMAKIDQIIEYIF
MSDEKKYIPKKGDIVWIDFDPSAEKEIQKRRPGLVVSRYEFNRKTLFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFAERKLSQIEHLPLKDMAKIDQIIEYIF
Download Length: 342 bp
>T208900 NZ_CP103755:1934050-1934301 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8510.42 Da Isoelectric Point: 4.3855
>AT208900 WP_002362431.1 NZ_CP078016:c30133-29903 [Enterococcus faecalis]
MLTTKSRKQGSSVVLTLPSNNGQKPKADQEYIVMYSDDGTITLVPKLQDPFSGGSEGEYYEKDEWHDIEPGGRELF
MLTTKSRKQGSSVVLTLPSNNGQKPKADQEYIVMYSDDGTITLVPKLQDPFSGGSEGEYYEKDEWHDIEPGGRELF
Download Length: 231 bp
>AT208900 NZ_CP103755:1934298-1934552 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2Z2CGM4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | R3KHK9 |