Detailed information of TA system TA208882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2499783..2500396
• Replicon: chromosome
• Accession: NZ_CP078013
• Organism: Pseudomonas pergaminensis strain 1008

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KUA23_RS11620
• Protein ID: WP_214497546.1
• Coordinates: 2500145..2500396 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KUA23_RS11615
• Protein ID: WP_078047963.1
• Coordinates: 2499783..2500148 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUA23_RS11595 (KUA23_11540)	2495521..2496504	+	984	WP_214497544.1	AAA family ATPase	-
KUA23_RS11600 (KUA23_11545)	2496542..2497897	+	1356	WP_252993974.1	MATE family efflux transporter	-
KUA23_RS11605 (KUA23_11550)	2497881..2498468	-	588	WP_252993975.1	TetR/AcrR family transcriptional regulator	-
KUA23_RS11610 (KUA23_11555)	2498610..2499782	+	1173	WP_252993976.1	MFS transporter	-
KUA23_RS11615 (KUA23_11560)	2499783..2500148	-	366	WP_078047963.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KUA23_RS11620 (KUA23_11565)	2500145..2500396	-	252	WP_214497546.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9531.05 Da
• Isoelectric Point: 10.3136

>T208882 WP_214497546.1 NZ_CP078013:c2500396-2500145 [Pseudomonas pergaminensis]
VSKNEKLLAKLLNEHTAFTWPERVTLLRRLGYTQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Nucleotide

• Length: 252 bp

>T208882 NZ_CP103751:c1063991-1063773 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTCGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAACTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13150.92 Da
• Isoelectric Point: 6.6267

>AT208882 WP_078047963.1 NZ_CP078013:c2500148-2499783 [Pseudomonas pergaminensis]
VNNQLQHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDGAFREAVDDYLATCQALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHGNDPCPAVS

Nucleotide

• Length: 366 bp

>AT208882 NZ_CP103751:c1064393-1064019 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA