Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 4616836..4618094 | Replicon | chromosome |
| Accession | NZ_CP078009 | ||
| Organism | Pseudomonas aeruginosa strain FAHZU31 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9I4U4 |
| Locus tag | KUU74_RS21505 | Protein ID | WP_003112528.1 |
| Coordinates | 4616836..4617591 (-) | Length | 252 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | V6AJU7 |
| Locus tag | KUU74_RS21510 | Protein ID | WP_003086329.1 |
| Coordinates | 4617726..4618094 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KUU74_RS21495 (KUU74_21490) | 4612009..4614552 | + | 2544 | WP_003112526.1 | acyl-homoserine-lactone acylase QuiP | - |
| KUU74_RS21500 (KUU74_21495) | 4614707..4616068 | - | 1362 | WP_010895536.1 | DNA recombination protein RmuC | - |
| KUU74_RS21505 (KUU74_21500) | 4616836..4617591 | - | 756 | WP_003112528.1 | RES family NAD+ phosphorylase | Toxin |
| KUU74_RS21510 (KUU74_21505) | 4617726..4618094 | - | 369 | WP_003086329.1 | DUF2384 domain-containing protein | Antitoxin |
| KUU74_RS21515 (KUU74_21510) | 4618167..4619453 | - | 1287 | WP_003112529.1 | FAD-binding oxidoreductase | - |
| KUU74_RS21520 (KUU74_21515) | 4619509..4621098 | - | 1590 | WP_003123191.1 | aldehyde dehydrogenase family protein | - |
| KUU74_RS21525 (KUU74_21520) | 4621177..4621653 | + | 477 | WP_003112531.1 | hypothetical protein | - |
| KUU74_RS21530 (KUU74_21525) | 4621656..4621931 | - | 276 | WP_010793902.1 | zinc ribbon domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 252 a.a. Molecular weight: 28278.42 Da Isoelectric Point: 7.7294
>T208877 WP_003112528.1 NZ_CP078009:c4617591-4616836 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA
Download Length: 756 bp
>T208877 NZ_CP103746:c40615-40466 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACTGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACTGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13367.63 Da Isoelectric Point: 9.9874
>AT208877 WP_003086329.1 NZ_CP078009:c4618094-4617726 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
Download Length: 369 bp
>AT208877 NZ_CP103746:40659-40720 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|