Detailed information of TA system TA208876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3635594..3636815
• Replicon: chromosome
• Accession: NZ_CP078009
• Organism: Pseudomonas aeruginosa strain FAHZU31

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: KUU74_RS16880
• Protein ID: WP_003102740.1
• Coordinates: 3636237..3636815 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KUU74_RS16875
• Protein ID: WP_003088112.1
• Coordinates: 3635594..3636148 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU74_RS16850 (KUU74_16850)	3631162..3631713	+	552	WP_004343115.1	XRE family transcriptional regulator	-
KUU74_RS16855 (KUU74_16855)	3631710..3632108	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
KUU74_RS16860 (KUU74_16860)	3632121..3632444	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
KUU74_RS16865 (KUU74_16865)	3632775..3633236	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
KUU74_RS16870 (KUU74_16870)	3633241..3635436	+	2196	WP_010794059.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
KUU74_RS16875 (KUU74_16875)	3635594..3636148	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
KUU74_RS16880 (KUU74_16880)	3636237..3636815	+	579	WP_003102740.1	HD domain-containing protein	Toxin
KUU74_RS16885 (KUU74_16885)	3636924..3638111	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
KUU74_RS16890 (KUU74_16890)	3638101..3640272	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
KUU74_RS16895 (KUU74_16895)	3640262..3641539	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T208876 WP_003102740.1 NZ_CP078009:3636237-3636815 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T208876 NZ_CP103746:c37571-37284 [Escherichia coli]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT208876 WP_003088112.1 NZ_CP078009:3635594-3636148 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT208876 NZ_CP103746:c37819-37568 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07