Detailed information of TA system TA208873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 1583126..1584821
• Replicon: chromosome
• Accession: NZ_CP078009
• Organism: Pseudomonas aeruginosa strain FAHZU31

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q9HYA0
• Locus tag: KUU74_RS07370
• Protein ID: WP_003112901.1
• Coordinates: 1583126..1583995 (+)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: Q9HYA1
• Locus tag: KUU74_RS07375
• Protein ID: WP_003112902.1
• Coordinates: 1583988..1584821 (+)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU74_RS07345 (KUU74_07345)	1579134..1579985	+	852	WP_003130104.1	ABC transporter ATP-binding protein	-
KUU74_RS07350 (KUU74_07350)	1580026..1581033	+	1008	WP_003112897.1	ABC transporter substrate-binding protein	-
KUU74_RS07355 (KUU74_07355)	1581030..1581806	+	777	WP_003112898.1	ABC transporter permease	-
KUU74_RS07360 (KUU74_07360)	1581812..1582573	+	762	WP_003112899.1	SDR family oxidoreductase	-
KUU74_RS07365 (KUU74_07365)	1582587..1583117	+	531	WP_003112900.1	cupin domain-containing protein	-
KUU74_RS07370 (KUU74_07370)	1583126..1583995	+	870	WP_003112901.1	alpha/beta hydrolase	Toxin
KUU74_RS07375 (KUU74_07375)	1583988..1584821	+	834	WP_003112902.1	IclR family transcriptional regulator	Antitoxin
KUU74_RS07380 (KUU74_07380)	1584808..1585605	+	798	WP_003112903.1	SDR family oxidoreductase	-
KUU74_RS07385 (KUU74_07385)	1585598..1587280	+	1683	WP_003130114.1	thiamine pyrophosphate-binding protein	-
KUU74_RS07390 (KUU74_07390)	1587291..1588094	+	804	WP_003130116.1	aspartate dehydrogenase	-
KUU74_RS07395 (KUU74_07395)	1588106..1589590	+	1485	WP_003453562.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (41-272)

Antitoxin

• Transcription regulator IclR, N-terminal (16-66)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 30403.60 Da
• Isoelectric Point: 6.5894

>T208873 WP_003112901.1 NZ_CP078009:1583126-1583995 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Nucleotide

• Length: 870 bp

>T208873 NZ_CP103745:c4194671-4194384 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCAACCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30877.26 Da
• Isoelectric Point: 5.7725

>AT208873 WP_003112902.1 NZ_CP078009:1583988-1584821 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Nucleotide

• Length: 834 bp

>AT208873 NZ_CP103745:c4194397-4194095 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: Q9HYA0

Antitoxin

• AlphaFold DB: Q9HYA1