208872

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143178..143683 Replicon chromosome
Accession NZ_CP078009
Organism Pseudomonas aeruginosa strain FAHZU31

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag KUU74_RS00660 Protein ID WP_003083773.1
Coordinates 143178..143459 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag KUU74_RS00665 Protein ID WP_003083775.1
Coordinates 143456..143683 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU74_RS00635 (KUU74_00635) 138429..139778 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
KUU74_RS00640 (KUU74_00640) 139827..140513 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KUU74_RS00645 (KUU74_00645) 140614..141348 + 735 WP_003117208.1 GntR family transcriptional regulator -
KUU74_RS00650 (KUU74_00650) 141528..141938 + 411 WP_003101225.1 aegerolysin family protein -
KUU74_RS00655 (KUU74_00655) 141970..142878 - 909 WP_010793581.1 LysR family transcriptional regulator -
KUU74_RS00660 (KUU74_00660) 143178..143459 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
KUU74_RS00665 (KUU74_00665) 143456..143683 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
KUU74_RS00670 (KUU74_00670) 143859..144479 - 621 WP_003101226.1 hypothetical protein -
KUU74_RS00675 (KUU74_00675) 144580..145080 + 501 WP_003101228.1 LEA type 2 family protein -
KUU74_RS00680 (KUU74_00680) 145153..145494 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KUU74_RS00685 (KUU74_00685) 145576..147003 - 1428 WP_003083784.1 GABA permease -
KUU74_RS00690 (KUU74_00690) 147172..148665 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T208872 WP_003083773.1 NZ_CP078009:c143459-143178 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T208872 NZ_CP103745:3860178-3860456 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT208872 WP_003083775.1 NZ_CP078009:c143683-143456 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT208872 NZ_CP103745:3859915-3860175 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References