Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1667538..1668150 Replicon chromosome
Accession NC_004606
Organism Streptococcus pyogenes SSI-1

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag SPS_RS08610 Protein ID WP_002982731.1
Coordinates 1667815..1668150 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5S4TJ53
Locus tag SPS_RS08605 Protein ID WP_011055007.1
Coordinates 1667538..1667825 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPS_RS08580 1662730..1663713 - 984 WP_011055003.1 tagatose-bisphosphate aldolase -
SPS_RS08585 1663717..1664646 - 930 WP_011055004.1 tagatose-6-phosphate kinase -
SPS_RS08590 1664692..1665207 - 516 WP_011055005.1 galactose-6-phosphate isomerase subunit LacB -
SPS_RS08595 1665242..1665670 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
SPS_RS08600 1666115..1666888 + 774 WP_011055006.1 DeoR/GlpR family DNA-binding transcription regulator -
SPS_RS08605 1667538..1667825 + 288 WP_011055007.1 hypothetical protein Antitoxin
SPS_RS08610 1667815..1668150 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPS_RS10375 1668217..1669288 + 1072 Protein_1652 site-specific integrase -
SPS_RS08620 1669420..1669812 - 393 WP_002982716.1 30S ribosomal protein S9 -
SPS_RS08625 1669833..1670279 - 447 WP_002982710.1 50S ribosomal protein L13 -
SPS_RS08630 1670497..1670703 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
SPS_RS08635 1670700..1671398 - 699 WP_011055008.1 hypothetical protein -
SPS_RS08640 1671525..1672385 - 861 WP_011055009.1 DegV family protein -
SPS_RS08645 1672482..1673000 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T20887 WP_002982731.1 NC_004606:1667815-1668150 [Streptococcus pyogenes SSI-1]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T20887 NC_004606:1667815-1668150 [Streptococcus pyogenes SSI-1]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 5.2318

>AT20887 WP_011055007.1 NC_004606:1667538-1667825 [Streptococcus pyogenes SSI-1]
MTTVKKNRTVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT20887 NC_004606:1667538-1667825 [Streptococcus pyogenes SSI-1]
ATGACTACAGTAAAAAAAAACAGAACGGTTACCTTTCAAGCTAATAAAGAACTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A5S4TJ53

References