Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 155702..156207 Replicon chromosome
Accession NZ_CP078007
Organism Pseudomonas aeruginosa strain FAHZU40

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KUU69_RS00695 Protein ID WP_034037564.1
Coordinates 155702..155983 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag KUU69_RS00700 Protein ID WP_003083775.1
Coordinates 155980..156207 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU69_RS00670 (KUU69_00670) 150953..152302 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
KUU69_RS00675 (KUU69_00675) 152351..153037 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KUU69_RS00680 (KUU69_00680) 153138..153872 + 735 WP_003117208.1 GntR family transcriptional regulator -
KUU69_RS00685 (KUU69_00685) 154052..154462 + 411 WP_003101225.1 aegerolysin family protein -
KUU69_RS00690 (KUU69_00690) 154494..155402 - 909 WP_016561475.1 LysR family transcriptional regulator -
KUU69_RS00695 (KUU69_00695) 155702..155983 - 282 WP_034037564.1 type II toxin-antitoxin system toxin ParE Toxin
KUU69_RS00700 (KUU69_00700) 155980..156207 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
KUU69_RS00705 (KUU69_00705) 156383..157003 - 621 WP_003101226.1 hypothetical protein -
KUU69_RS00710 (KUU69_00710) 157104..157604 + 501 WP_003101228.1 LEA type 2 family protein -
KUU69_RS00715 (KUU69_00715) 157677..158018 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KUU69_RS00720 (KUU69_00720) 158100..159527 - 1428 WP_003083784.1 GABA permease -
KUU69_RS00725 (KUU69_00725) 159696..161189 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10458.20 Da        Isoelectric Point: 10.0435

>T208867 WP_034037564.1 NZ_CP078007:c155983-155702 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T208867 NZ_CP103745:2681762-2681869 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT208867 WP_003083775.1 NZ_CP078007:c156207-155980 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT208867 NZ_CP103745:c2681715-2681649 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References