Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3420111..3421331 Replicon chromosome
Accession NZ_CP078006
Organism Pseudomonas aeruginosa strain NDTH7329

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KUU80_RS15820 Protein ID WP_003160088.1
Coordinates 3420753..3421331 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KUU80_RS15815 Protein ID WP_003088112.1
Coordinates 3420111..3420665 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU80_RS15790 (KUU80_15785) 3415679..3416230 + 552 WP_003132721.1 XRE family transcriptional regulator -
KUU80_RS15795 (KUU80_15790) 3416227..3416625 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KUU80_RS15800 (KUU80_15795) 3416638..3416961 - 324 WP_003102734.1 multidrug efflux SMR transporter -
KUU80_RS15805 (KUU80_15800) 3417292..3417753 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
KUU80_RS15810 (KUU80_15805) 3417758..3419953 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KUU80_RS15815 (KUU80_15810) 3420111..3420665 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KUU80_RS15820 (KUU80_15815) 3420753..3421331 + 579 WP_003160088.1 HD domain-containing protein Toxin
KUU80_RS15825 (KUU80_15820) 3421440..3422627 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KUU80_RS15830 (KUU80_15825) 3422617..3424788 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
KUU80_RS15835 (KUU80_15830) 3424778..3426055 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T208862 WP_003160088.1 NZ_CP078006:3420753-3421331 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T208862 NZ_CP103745:1845465-1845719 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT208862 WP_003088112.1 NZ_CP078006:3420111-3420665 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT208862 NZ_CP103745:1845217-1845468 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References