Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3753341..3754561 Replicon chromosome
Accession NZ_CP078004
Organism Pseudomonas aeruginosa strain QZPH16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KUU76_RS17215 Protein ID WP_003160088.1
Coordinates 3753983..3754561 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KUU76_RS17210 Protein ID WP_003088112.1
Coordinates 3753341..3753895 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU76_RS17185 (KUU76_17185) 3748909..3749460 + 552 WP_003132721.1 XRE family transcriptional regulator -
KUU76_RS17190 (KUU76_17190) 3749457..3749855 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KUU76_RS17195 (KUU76_17195) 3749868..3750191 - 324 WP_003102734.1 multidrug efflux SMR transporter -
KUU76_RS17200 (KUU76_17200) 3750522..3750983 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
KUU76_RS17205 (KUU76_17205) 3750988..3753183 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KUU76_RS17210 (KUU76_17210) 3753341..3753895 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KUU76_RS17215 (KUU76_17215) 3753983..3754561 + 579 WP_003160088.1 HD domain-containing protein Toxin
KUU76_RS17220 (KUU76_17220) 3754670..3755857 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KUU76_RS17225 (KUU76_17225) 3755847..3758018 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
KUU76_RS17230 (KUU76_17230) 3758008..3759285 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T208854 WP_003160088.1 NZ_CP078004:3753983-3754561 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T208854 NZ_CP103745:185133-185240 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT208854 WP_003088112.1 NZ_CP078004:3753341-3753895 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT208854 NZ_CP103745:c185085-185019 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References