208846

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3548850..3550070 Replicon chromosome
Accession NZ_CP078002
Organism Pseudomonas aeruginosa strain QZPH21

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KUU68_RS16305 Protein ID WP_003160088.1
Coordinates 3549492..3550070 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KUU68_RS16300 Protein ID WP_003088112.1
Coordinates 3548850..3549404 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU68_RS16275 (KUU68_16275) 3544418..3544969 + 552 WP_003132721.1 XRE family transcriptional regulator -
KUU68_RS16280 (KUU68_16280) 3544966..3545364 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KUU68_RS16285 (KUU68_16285) 3545377..3545700 - 324 WP_003102734.1 multidrug efflux SMR transporter -
KUU68_RS16290 (KUU68_16290) 3546031..3546492 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
KUU68_RS16295 (KUU68_16295) 3546497..3548692 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KUU68_RS16300 (KUU68_16300) 3548850..3549404 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KUU68_RS16305 (KUU68_16305) 3549492..3550070 + 579 WP_003160088.1 HD domain-containing protein Toxin
KUU68_RS16310 (KUU68_16310) 3550179..3551366 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KUU68_RS16315 (KUU68_16315) 3551356..3553527 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
KUU68_RS16320 (KUU68_16320) 3553517..3554794 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T208846 WP_003160088.1 NZ_CP078002:3549492-3550070 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T208846 NZ_CP103742:c3961571-3961257 [Escherichia coli O25b:H4-ST131]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT208846 WP_003088112.1 NZ_CP078002:3548850-3549404 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT208846 NZ_CP103742:c3961807-3961574 [Escherichia coli O25b:H4-ST131]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References