Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 176108..176613 Replicon chromosome
Accession NZ_CP078002
Organism Pseudomonas aeruginosa strain QZPH21

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag KUU68_RS00815 Protein ID WP_003121619.1
Coordinates 176108..176389 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag KUU68_RS00820 Protein ID WP_003112628.1
Coordinates 176386..176613 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU68_RS00790 (KUU68_00790) 171359..172708 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
KUU68_RS00795 (KUU68_00795) 172757..173443 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KUU68_RS00800 (KUU68_00800) 173544..174278 + 735 WP_003117208.1 GntR family transcriptional regulator -
KUU68_RS00805 (KUU68_00805) 174458..174868 + 411 WP_003101225.1 aegerolysin family protein -
KUU68_RS00810 (KUU68_00810) 174900..175808 - 909 WP_016561475.1 LysR family transcriptional regulator -
KUU68_RS00815 (KUU68_00815) 176108..176389 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
KUU68_RS00820 (KUU68_00820) 176386..176613 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
KUU68_RS00825 (KUU68_00825) 176789..177409 - 621 WP_003101226.1 hypothetical protein -
KUU68_RS00830 (KUU68_00830) 177510..178010 + 501 WP_003112629.1 LEA type 2 family protein -
KUU68_RS00835 (KUU68_00835) 178083..178424 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KUU68_RS00840 (KUU68_00840) 178506..179933 - 1428 WP_003083784.1 GABA permease -
KUU68_RS00845 (KUU68_00845) 180102..181595 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T208843 WP_003121619.1 NZ_CP078002:c176389-176108 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T208843 NZ_CP103742:c3519100-3518798 [Escherichia coli O25b:H4-ST131]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT208843 WP_003112628.1 NZ_CP078002:c176613-176386 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT208843 NZ_CP103742:c3518762-3518421 [Escherichia coli O25b:H4-ST131]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References