Detailed information of TA system TA208838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3766933..3768153
• Replicon: chromosome
• Accession: NZ_CP077999
• Organism: Pseudomonas aeruginosa strain SRRSH1120

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KUU71_RS17240
• Protein ID: WP_003160088.1
• Coordinates: 3767575..3768153 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KUU71_RS17235
• Protein ID: WP_003088112.1
• Coordinates: 3766933..3767487 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU71_RS17210 (KUU71_17210)	3762501..3763052	+	552	WP_003132721.1	XRE family transcriptional regulator	-
KUU71_RS17215 (KUU71_17215)	3763049..3763447	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
KUU71_RS17220 (KUU71_17220)	3763460..3763783	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
KUU71_RS17225 (KUU71_17225)	3764114..3764575	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
KUU71_RS17230 (KUU71_17230)	3764580..3766775	+	2196	WP_003122807.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
KUU71_RS17235 (KUU71_17235)	3766933..3767487	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
KUU71_RS17240 (KUU71_17240)	3767575..3768153	+	579	WP_003160088.1	HD domain-containing protein	Toxin
KUU71_RS17245 (KUU71_17245)	3768262..3769449	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
KUU71_RS17250 (KUU71_17250)	3769439..3771610	-	2172	WP_009876279.1	type I secretion system permease/ATPase	-
KUU71_RS17255 (KUU71_17255)	3771600..3772877	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21816.65 Da
• Isoelectric Point: 5.1625

>T208838 WP_003160088.1 NZ_CP077999:3767575-3768153 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Nucleotide

• Length: 579 bp

>T208838 NZ_CP103742:c1877710-1877336 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTACTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT208838 WP_003088112.1 NZ_CP077999:3766933-3767487 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT208838 NZ_CP103742:c1878167-1877799 [Escherichia coli O25b:H4-ST131]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCAGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA