Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1904619..1906127 Replicon chromosome
Accession NZ_CP077999
Organism Pseudomonas aeruginosa strain SRRSH1120

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag KUU71_RS08835 Protein ID WP_003119682.1
Coordinates 1904619..1905206 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag KUU71_RS08840 Protein ID WP_003119683.1
Coordinates 1905273..1906127 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU71_RS08830 (KUU71_08830) 1900874..1904353 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
KUU71_RS08835 (KUU71_08835) 1904619..1905206 + 588 WP_003119682.1 GNAT family protein Toxin
KUU71_RS08840 (KUU71_08840) 1905273..1906127 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
KUU71_RS08845 (KUU71_08845) 1906224..1908389 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
KUU71_RS08850 (KUU71_08850) 1908564..1910438 + 1875 WP_003091605.1 MFS transporter -
KUU71_RS08855 (KUU71_08855) 1910499..1910708 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T208837 WP_003119682.1 NZ_CP077999:1904619-1905206 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T208837 NZ_CP103742:1864674-1864928 [Escherichia coli O25b:H4-ST131]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT208837 WP_003119683.1 NZ_CP077999:1905273-1906127 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT208837 NZ_CP103742:1864426-1864677 [Escherichia coli O25b:H4-ST131]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References