Detailed information of TA system TA208832

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3583192..3584413
• Replicon: chromosome
• Accession: NZ_CP077997
• Organism: Pseudomonas aeruginosa strain SRRSH1521

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: KUU75_RS16495
• Protein ID: WP_003102740.1
• Coordinates: 3583835..3584413 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KUU75_RS16490
• Protein ID: WP_003088112.1
• Coordinates: 3583192..3583746 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU75_RS16465 (KUU75_16465)	3578760..3579311	+	552	WP_004343115.1	XRE family transcriptional regulator	-
KUU75_RS16470 (KUU75_16470)	3579308..3579706	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
KUU75_RS16475 (KUU75_16475)	3579719..3580042	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
KUU75_RS16480 (KUU75_16480)	3580373..3580834	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
KUU75_RS16485 (KUU75_16485)	3580839..3583034	+	2196	WP_010794059.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
KUU75_RS16490 (KUU75_16490)	3583192..3583746	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
KUU75_RS16495 (KUU75_16495)	3583835..3584413	+	579	WP_003102740.1	HD domain-containing protein	Toxin
KUU75_RS16500 (KUU75_16500)	3584522..3585709	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
KUU75_RS16505 (KUU75_16505)	3585699..3587870	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
KUU75_RS16510 (KUU75_16510)	3587860..3589137	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T208832 WP_003102740.1 NZ_CP077997:3583835-3584413 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T208832 NZ_CP103742:c602505-602041 [Escherichia coli O25b:H4-ST131]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT208832 WP_003088112.1 NZ_CP077997:3583192-3583746 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT208832 NZ_CP103742:c602840-602505 [Escherichia coli O25b:H4-ST131]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07