Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 176114..176619 Replicon chromosome
Accession NZ_CP077994
Organism Pseudomonas aeruginosa strain SRRSH2790

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag KUU72_RS00815 Protein ID WP_003121619.1
Coordinates 176114..176395 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag KUU72_RS00820 Protein ID WP_003112628.1
Coordinates 176392..176619 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU72_RS00790 (KUU72_00790) 171365..172714 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
KUU72_RS00795 (KUU72_00795) 172763..173449 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KUU72_RS00800 (KUU72_00800) 173550..174284 + 735 WP_003117208.1 GntR family transcriptional regulator -
KUU72_RS00805 (KUU72_00805) 174464..174874 + 411 WP_003101225.1 aegerolysin family protein -
KUU72_RS00810 (KUU72_00810) 174906..175814 - 909 WP_016561475.1 LysR family transcriptional regulator -
KUU72_RS00815 (KUU72_00815) 176114..176395 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
KUU72_RS00820 (KUU72_00820) 176392..176619 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
KUU72_RS00825 (KUU72_00825) 176795..177415 - 621 WP_003101226.1 hypothetical protein -
KUU72_RS00830 (KUU72_00830) 177516..178016 + 501 WP_003112629.1 LEA type 2 family protein -
KUU72_RS00835 (KUU72_00835) 178089..178430 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KUU72_RS00840 (KUU72_00840) 178512..179939 - 1428 WP_003083784.1 GABA permease -
KUU72_RS00845 (KUU72_00845) 180108..181601 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T208819 WP_003121619.1 NZ_CP077994:c176395-176114 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T208819 NZ_CP103739:c3878740-3878405 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT208819 WP_003112628.1 NZ_CP077994:c176619-176392 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT208819 NZ_CP103739:c3878988-3878740 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References