208816

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4976144..4976752 Replicon chromosome
Accession NZ_CP077988
Organism Pseudomonas aeruginosa strain ZPPH1

Toxin (Protein)


Gene name PfiT Uniprot ID A0A509JBR4
Locus tag KUU79_RS23435 Protein ID WP_031638390.1
Coordinates 4976144..4976491 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag KUU79_RS23440 Protein ID WP_003114155.1
Coordinates 4976501..4976752 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU79_RS23410 (KUU79_23395) 4973010..4973393 + 384 WP_088376624.1 hypothetical protein -
KUU79_RS23415 (KUU79_23400) 4973390..4973794 + 405 WP_058171606.1 hypothetical protein -
KUU79_RS23420 (KUU79_23405) 4973784..4973990 + 207 WP_033989513.1 AlpA family phage regulatory protein -
KUU79_RS23425 (KUU79_23410) 4973987..4974607 - 621 WP_124207766.1 hypothetical protein -
KUU79_RS23430 (KUU79_23415) 4974623..4975825 - 1203 WP_034075497.1 integrase family protein -
KUU79_RS23435 (KUU79_23420) 4976144..4976491 - 348 WP_031638390.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUU79_RS23440 (KUU79_23425) 4976501..4976752 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KUU79_RS23445 (KUU79_23430) 4976966..4977949 - 984 WP_034014422.1 tyrosine-type recombinase/integrase -
KUU79_RS23450 (KUU79_23435) 4977949..4979241 - 1293 WP_003123045.1 hypothetical protein -
KUU79_RS23455 (KUU79_23440) 4979500..4980762 - 1263 WP_033953311.1 zonular occludens toxin domain-containing protein -
KUU79_RS23460 (KUU79_23445) 4980764..4981114 - 351 WP_003133726.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4935597..4998350 62753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13018.79 Da        Isoelectric Point: 4.4212

>T208816 WP_031638390.1 NZ_CP077988:c4976491-4976144 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T208816 NZ_CP103739:c2808499-2808396 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT208816 WP_003114155.1 NZ_CP077988:c4976752-4976501 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT208816 NZ_CP103739:2808358-2808629 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A509JBR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References