Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3676057..3677278 Replicon chromosome
Accession NZ_CP077988
Organism Pseudomonas aeruginosa strain ZPPH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KUU79_RS17215 Protein ID WP_003114949.1
Coordinates 3676700..3677278 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KUU79_RS17210 Protein ID WP_003088112.1
Coordinates 3676057..3676611 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU79_RS17185 (KUU79_17175) 3671625..3672176 + 552 WP_003102727.1 XRE family transcriptional regulator -
KUU79_RS17190 (KUU79_17180) 3672173..3672571 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KUU79_RS17195 (KUU79_17185) 3672584..3672907 - 324 WP_003162861.1 multidrug efflux SMR transporter -
KUU79_RS17200 (KUU79_17190) 3673238..3673699 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
KUU79_RS17205 (KUU79_17195) 3673704..3675899 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KUU79_RS17210 (KUU79_17200) 3676057..3676611 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KUU79_RS17215 (KUU79_17205) 3676700..3677278 + 579 WP_003114949.1 HD domain-containing protein Toxin
KUU79_RS17220 (KUU79_17210) 3677386..3678573 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KUU79_RS17225 (KUU79_17215) 3678563..3680734 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
KUU79_RS17230 (KUU79_17220) 3680724..3682001 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T208814 WP_003114949.1 NZ_CP077988:3676700-3677278 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T208814 NZ_CP103739:2415510-2415686 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT208814 WP_003088112.1 NZ_CP077988:3676057-3676611 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT208814 NZ_CP103739:2415732-2416148 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References