Detailed information of TA system TA208813

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1951106..1952614
• Replicon: chromosome
• Accession: NZ_CP077988
• Organism: Pseudomonas aeruginosa strain ZPPH1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KUU79_RS09270
• Protein ID: WP_012613851.1
• Coordinates: 1951106..1951693 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KUU79_RS09275
• Protein ID: WP_012613852.1
• Coordinates: 1951760..1952614 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU79_RS09265 (KUU79_09265)	1947361..1950840	-	3480	WP_003117605.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
KUU79_RS09270 (KUU79_09270)	1951106..1951693	+	588	WP_012613851.1	GNAT family protein	Toxin
KUU79_RS09275 (KUU79_09275)	1951760..1952614	+	855	WP_012613852.1	AraC family transcriptional regulator	Antitoxin
KUU79_RS09280 (KUU79_09280)	1952711..1954876	+	2166	WP_003091606.1	TonB-dependent receptor family protein	-
KUU79_RS09285 (KUU79_09285)	1955051..1956925	+	1875	WP_187787342.1	MFS transporter	-
KUU79_RS09290 (KUU79_09290)	1956986..1957195	-	210	WP_003091604.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T208813 WP_012613851.1 NZ_CP077988:1951106-1951693 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

>T208813 NZ_CP103739:c2303253-2303059 [Escherichia coli]
TTGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGACATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCGCTCGAAAGATGGAATAAACGAA
CCACTGAAAATATTAATGGAGGCGTTCATGTATAA

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31959.27 Da
• Isoelectric Point: 7.3276

>AT208813 WP_012613852.1 NZ_CP077988:1951760-1952614 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp

>AT208813 NZ_CP103739:2302882-2303060 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT