208810

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 6640924..6641532 Replicon chromosome
Accession NZ_CP077985
Organism Pseudomonas aeruginosa strain ZPPH2

Toxin (Protein)


Gene name PfiT Uniprot ID -
Locus tag KUU77_RS31165 Protein ID WP_016263850.1
Coordinates 6641185..6641532 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag KUU77_RS31160 Protein ID WP_003114155.1
Coordinates 6640924..6641175 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU77_RS31140 (KUU77_31125) 6636562..6636912 + 351 WP_003133726.1 DUF2523 family protein -
KUU77_RS31145 (KUU77_31130) 6636914..6638176 + 1263 WP_033953311.1 zonular occludens toxin domain-containing protein -
KUU77_RS31150 (KUU77_31135) 6638435..6639727 + 1293 WP_003123045.1 hypothetical protein -
KUU77_RS31155 (KUU77_31140) 6639727..6640710 + 984 WP_019725833.1 tyrosine-type recombinase/integrase -
KUU77_RS31160 (KUU77_31145) 6640924..6641175 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KUU77_RS31165 (KUU77_31150) 6641185..6641532 + 348 WP_016263850.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUU77_RS31170 (KUU77_31155) 6641816..6642130 - 315 WP_014703526.1 DUF736 domain-containing protein -
KUU77_RS31175 (KUU77_31160) 6642908..6643117 - 210 WP_023110658.1 hypothetical protein -
KUU77_RS31180 (KUU77_31165) 6643180..6645237 - 2058 WP_014703524.1 ParB/RepB/Spo0J family partition protein -
KUU77_RS31185 (KUU77_31170) 6645312..6646142 - 831 WP_023110659.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaOXA-396 - 6586876..6673813 86937


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13046.85 Da        Isoelectric Point: 4.4212

>T208810 WP_016263850.1 NZ_CP077985:6641185-6641532 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T208810 NZ_CP103739:c2161247-2161140 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT208810 WP_003114155.1 NZ_CP077985:6640924-6641175 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT208810 NZ_CP103739:2161295-2161361 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References