Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1790464..1791086 Replicon chromosome
Accession NC_004578
Organism Pseudomonas syringae pv. tomato str. DC3000

Toxin (Protein)


Gene name hicA Uniprot ID Q886E5
Locus tag PSPTO_RS08525 Protein ID WP_011103638.1
Coordinates 1790464..1790646 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q886E4
Locus tag PSPTO_RS08530 Protein ID WP_005767619.1
Coordinates 1790682..1791086 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSPTO_RS08515 1786655..1788403 - 1749 WP_005767614.1 N-acetylglutaminylglutamine synthetase -
PSPTO_RS08520 1788407..1790179 - 1773 WP_011103637.1 N-acetylglutaminylglutamine amidotransferase -
PSPTO_RS08525 1790464..1790646 + 183 WP_011103638.1 type II toxin-antitoxin system HicA family toxin Toxin
PSPTO_RS08530 1790682..1791086 + 405 WP_005767619.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PSPTO_RS08535 1791102..1792181 - 1080 WP_046463929.1 iron ABC transporter permease -
PSPTO_RS08540 1792171..1794648 - 2478 WP_011103640.1 ABC transporter permease -
PSPTO_RS08545 1794648..1795316 - 669 WP_011103641.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6675.81 Da        Isoelectric Point: 10.6643

>T20881 WP_011103638.1 NC_004578:1790464-1790646 [Pseudomonas syringae pv. tomato str. DC3000]
VQSRQLVKELEADGWVLDRVTGSHHMFKHPEKSQTVPVPHPKKDLPLGTVKAIRKLAGLA

Download         Length: 183 bp

>T20881 NC_004578:1790464-1790646 [Pseudomonas syringae pv. tomato str. DC3000]
GTGCAAAGCAGGCAATTGGTAAAGGAGCTTGAAGCAGATGGTTGGGTTCTTGATCGTGTCACCGGCAGTCACCATATGTT
CAAACACCCAGAAAAGTCTCAAACAGTTCCGGTGCCGCATCCCAAGAAAGACTTGCCGCTTGGAACAGTAAAGGCCATCA
GAAAGCTTGCCGGATTGGCGTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14455.52 Da        Isoelectric Point: 4.9093

>AT20881 WP_005767619.1 NC_004578:1790682-1791086 [Pseudomonas syringae pv. tomato str. DC3000]
MKYPICIEWGDETTAFGIQIPDIPGAITAGDTFEEAHAAAVEIAHIMLQEIAASGGSIPKVGTVAEHAKNPDFSGMGWGM
LEIDVTPYLGKTEKVNVTLPGFVIRQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp

>AT20881 NC_004578:1790682-1791086 [Pseudomonas syringae pv. tomato str. DC3000]
ATGAAATATCCAATATGCATAGAGTGGGGCGATGAGACCACAGCGTTCGGCATTCAGATACCGGACATACCTGGTGCTAT
CACCGCAGGCGATACCTTTGAGGAGGCTCATGCGGCAGCCGTTGAGATCGCTCATATCATGCTGCAGGAGATTGCAGCCA
GTGGCGGGTCTATTCCGAAAGTCGGGACCGTTGCCGAGCATGCCAAAAACCCTGATTTTTCTGGAATGGGCTGGGGCATG
CTGGAAATCGATGTAACGCCTTATCTAGGCAAGACGGAAAAGGTCAACGTCACCTTGCCTGGCTTTGTGATCAGACAGAT
CGACCGCTACGTAAGGGATCACAGCATCAAAAGTCGCTCGACCTTCCTGGCTGATGCTGCGCTGGAAAAGCTCGGTCGAG
CGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q886E5

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3Z2W9

References