Detailed information of TA system TA208806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3651560..3652781
• Replicon: chromosome
• Accession: NZ_CP077985
• Organism: Pseudomonas aeruginosa strain ZPPH2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KUU77_RS17125
• Protein ID: WP_003114949.1
• Coordinates: 3652203..3652781 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KUU77_RS17120
• Protein ID: WP_003088112.1
• Coordinates: 3651560..3652114 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU77_RS17095 (KUU77_17085)	3647128..3647679	+	552	WP_003102727.1	XRE family transcriptional regulator	-
KUU77_RS17100 (KUU77_17090)	3647676..3648074	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
KUU77_RS17105 (KUU77_17095)	3648087..3648410	-	324	WP_003162861.1	multidrug efflux SMR transporter	-
KUU77_RS17110 (KUU77_17100)	3648741..3649202	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
KUU77_RS17115 (KUU77_17105)	3649207..3651402	+	2196	WP_004349295.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
KUU77_RS17120 (KUU77_17110)	3651560..3652114	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
KUU77_RS17125 (KUU77_17115)	3652203..3652781	+	579	WP_003114949.1	HD domain-containing protein	Toxin
KUU77_RS17130 (KUU77_17120)	3652889..3654076	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
KUU77_RS17135 (KUU77_17125)	3654066..3656237	-	2172	WP_009876279.1	type I secretion system permease/ATPase	-
KUU77_RS17140 (KUU77_17130)	3656227..3657504	-	1278	WP_003122808.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21897.75 Da
• Isoelectric Point: 5.3655

>T208806 WP_003114949.1 NZ_CP077985:3652203-3652781 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Nucleotide

• Length: 579 bp

>T208806 NZ_CP103739:751152-751529 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT208806 WP_003088112.1 NZ_CP077985:3651560-3652114 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT208806 NZ_CP103739:750694-751062 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA