208802

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4841937..4842545 Replicon chromosome
Accession NZ_CP077981
Organism Pseudomonas aeruginosa strain ZPPH14

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag KUU73_RS22325 Protein ID WP_003123043.1
Coordinates 4841937..4842284 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag KUU73_RS22330 Protein ID WP_003114155.1
Coordinates 4842294..4842545 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU73_RS22295 (KUU73_22290) 4837296..4837568 + 273 WP_003120794.1 cysteine-rich CWC family protein -
KUU73_RS22300 (KUU73_22295) 4837568..4838260 + 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
KUU73_RS22305 (KUU73_22300) 4838396..4839439 + 1044 WP_003098363.1 L,D-transpeptidase -
KUU73_RS22310 (KUU73_22305) 4839519..4840256 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
KUU73_RS22315 (KUU73_22310) 4840708..4841610 + 903 WP_003098365.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
KUU73_RS22325 (KUU73_22320) 4841937..4842284 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUU73_RS22330 (KUU73_22325) 4842294..4842545 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KUU73_RS22335 (KUU73_22330) 4842759..4843742 - 984 WP_124182454.1 tyrosine-type recombinase/integrase -
KUU73_RS22340 (KUU73_22335) 4843742..4845034 - 1293 WP_003123045.1 hypothetical protein -
KUU73_RS22345 (KUU73_22340) 4845684..4846073 - 390 WP_031687489.1 hypothetical protein -
KUU73_RS22350 (KUU73_22345) 4846066..4846281 - 216 WP_003123046.1 hypothetical protein -
KUU73_RS22355 (KUU73_22350) 4846304..4846519 - 216 WP_003123047.1 hypothetical protein -
KUU73_RS29900 4846637..4846906 + 270 WP_124182453.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T208802 WP_003123043.1 NZ_CP077981:c4842284-4841937 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T208802 NZ_CP103732:69132-69443 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT208802 WP_003114155.1 NZ_CP077981:c4842545-4842294 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT208802 NZ_CP103732:69440-69859 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References