Detailed information of TA system TA208800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4531024..4532282
• Replicon: chromosome
• Accession: NZ_CP077981
• Organism: Pseudomonas aeruginosa strain ZPPH14

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KUU73_RS20785
• Protein ID: WP_003163133.1
• Coordinates: 4531024..4531779 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: KUU73_RS20790
• Protein ID: WP_003086329.1
• Coordinates: 4531914..4532282 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU73_RS20775 (KUU73_20770)	4526196..4528739	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
KUU73_RS20780 (KUU73_20775)	4528894..4530255	-	1362	WP_073657578.1	DNA recombination protein RmuC	-
KUU73_RS20785 (KUU73_20780)	4531024..4531779	-	756	WP_003163133.1	RES family NAD+ phosphorylase	Toxin
KUU73_RS20790 (KUU73_20785)	4531914..4532282	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
KUU73_RS20795 (KUU73_20790)	4532355..4533641	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
KUU73_RS20800 (KUU73_20795)	4533697..4535286	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
KUU73_RS20805 (KUU73_20800)	4535365..4535841	+	477	WP_003112531.1	hypothetical protein	-
KUU73_RS20810 (KUU73_20805)	4535844..4536119	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28250.37 Da
• Isoelectric Point: 7.7294

>T208800 WP_003163133.1 NZ_CP077981:c4531779-4531024 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T208800 NZ_CP103731:c5382941-5382558 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT208800 WP_003086329.1 NZ_CP077981:c4532282-4531914 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT208800 NZ_CP103731:c5383183-5382941 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: V6AJU7