Detailed information of TA system TA208797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 144084..144589
• Replicon: chromosome
• Accession: NZ_CP077981
• Organism: Pseudomonas aeruginosa strain ZPPH14

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: KUU73_RS00670
• Protein ID: WP_003083773.1
• Coordinates: 144084..144365 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: KUU73_RS00675
• Protein ID: WP_003083775.1
• Coordinates: 144362..144589 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU73_RS00645 (KUU73_00645)	139335..140684	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
KUU73_RS00650 (KUU73_00650)	140733..141419	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
KUU73_RS00655 (KUU73_00655)	141520..142254	+	735	WP_003117208.1	GntR family transcriptional regulator	-
KUU73_RS00660 (KUU73_00660)	142434..142844	+	411	WP_003101225.1	aegerolysin family protein	-
KUU73_RS00665 (KUU73_00665)	142876..143784	-	909	WP_003083769.1	LysR family transcriptional regulator	-
KUU73_RS00670 (KUU73_00670)	144084..144365	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
KUU73_RS00675 (KUU73_00675)	144362..144589	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
KUU73_RS00680 (KUU73_00680)	144765..145385	-	621	WP_003101226.1	hypothetical protein	-
KUU73_RS00685 (KUU73_00685)	145486..145986	+	501	WP_003112629.1	LEA type 2 family protein	-
KUU73_RS00690 (KUU73_00690)	146059..146400	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
KUU73_RS00695 (KUU73_00695)	146482..147909	-	1428	WP_003083784.1	GABA permease	-
KUU73_RS00700 (KUU73_00700)	148078..149571	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T208797 WP_003083773.1 NZ_CP077981:c144365-144084 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T208797 NZ_CP103731:c4824563-4824186 [Klebsiella pneumoniae]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGACCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT208797 WP_003083775.1 NZ_CP077981:c144589-144362 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT208797 NZ_CP103731:c4825021-4824653 [Klebsiella pneumoniae]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCATGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9