Detailed information of TA system TA208792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3751033..3752254
• Replicon: chromosome
• Accession: NZ_CP077977
• Organism: Pseudomonas aeruginosa strain ZPPH29

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: KUU70_RS17640
• Protein ID: WP_003102740.1
• Coordinates: 3751676..3752254 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KUU70_RS17635
• Protein ID: WP_003088112.1
• Coordinates: 3751033..3751587 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU70_RS17610 (KUU70_17605)	3746601..3747152	+	552	WP_003102727.1	XRE family transcriptional regulator	-
KUU70_RS17615 (KUU70_17610)	3747149..3747547	-	399	WP_023082958.1	NADH-quinone oxidoreductase subunit A	-
KUU70_RS17620 (KUU70_17615)	3747560..3747883	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
KUU70_RS17625 (KUU70_17620)	3748214..3748675	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
KUU70_RS17630 (KUU70_17625)	3748680..3750875	+	2196	WP_004349295.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
KUU70_RS17635 (KUU70_17630)	3751033..3751587	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
KUU70_RS17640 (KUU70_17635)	3751676..3752254	+	579	WP_003102740.1	HD domain-containing protein	Toxin
KUU70_RS17645 (KUU70_17640)	3752363..3753550	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
KUU70_RS17650 (KUU70_17645)	3753540..3755711	-	2172	WP_009876279.1	type I secretion system permease/ATPase	-
KUU70_RS17655 (KUU70_17650)	3755701..3756978	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T208792 WP_003102740.1 NZ_CP077977:3751676-3752254 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T208792 NZ_CP103731:2013008-2013110 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT208792 WP_003088112.1 NZ_CP077977:3751033-3751587 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT208792 NZ_CP103731:c2013117-2012972 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Toxin

• AlphaFold DB: A0A0C7CS07