Detailed information of TA system TA208790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 145311..145816
• Replicon: chromosome
• Accession: NZ_CP077977
• Organism: Pseudomonas aeruginosa strain ZPPH29

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: KUU70_RS00680
• Protein ID: WP_003083773.1
• Coordinates: 145311..145592 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: KUU70_RS00685
• Protein ID: WP_003112628.1
• Coordinates: 145589..145816 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU70_RS00655 (KUU70_00655)	140562..141911	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
KUU70_RS00660 (KUU70_00660)	141960..142646	+	687	WP_004351997.1	FadR/GntR family transcriptional regulator	-
KUU70_RS00665 (KUU70_00665)	142747..143481	+	735	WP_003117208.1	GntR family transcriptional regulator	-
KUU70_RS00670 (KUU70_00670)	143661..144071	+	411	WP_003101225.1	aegerolysin family protein	-
KUU70_RS00675 (KUU70_00675)	144103..145011	-	909	WP_003083769.1	LysR family transcriptional regulator	-
KUU70_RS00680 (KUU70_00680)	145311..145592	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
KUU70_RS00685 (KUU70_00685)	145589..145816	-	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
KUU70_RS00690 (KUU70_00690)	145991..146611	-	621	WP_009314940.1	hypothetical protein	-
KUU70_RS00695 (KUU70_00695)	146719..147219	+	501	WP_003112629.1	LEA type 2 family protein	-
KUU70_RS00700 (KUU70_00700)	147292..147633	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
KUU70_RS00705 (KUU70_00705)	147715..149142	-	1428	WP_003083784.1	GABA permease	-
KUU70_RS00710 (KUU70_00710)	149311..150804	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T208790 WP_003083773.1 NZ_CP077977:c145592-145311 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T208790 NZ_CP103731:694764-695105 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT208790 WP_003112628.1 NZ_CP077977:c145816-145589 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT208790 NZ_CP103731:694426-694743 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: Q9I707