Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 145311..145816 | Replicon | chromosome |
| Accession | NZ_CP077977 | ||
| Organism | Pseudomonas aeruginosa strain ZPPH29 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | V6A7K8 |
| Locus tag | KUU70_RS00680 | Protein ID | WP_003083773.1 |
| Coordinates | 145311..145592 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q9I707 |
| Locus tag | KUU70_RS00685 | Protein ID | WP_003112628.1 |
| Coordinates | 145589..145816 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KUU70_RS00655 (KUU70_00655) | 140562..141911 | + | 1350 | WP_003142411.1 | C4-dicarboxylate transporter DctA | - |
| KUU70_RS00660 (KUU70_00660) | 141960..142646 | + | 687 | WP_004351997.1 | FadR/GntR family transcriptional regulator | - |
| KUU70_RS00665 (KUU70_00665) | 142747..143481 | + | 735 | WP_003117208.1 | GntR family transcriptional regulator | - |
| KUU70_RS00670 (KUU70_00670) | 143661..144071 | + | 411 | WP_003101225.1 | aegerolysin family protein | - |
| KUU70_RS00675 (KUU70_00675) | 144103..145011 | - | 909 | WP_003083769.1 | LysR family transcriptional regulator | - |
| KUU70_RS00680 (KUU70_00680) | 145311..145592 | - | 282 | WP_003083773.1 | type II toxin-antitoxin system toxin ParE | Toxin |
| KUU70_RS00685 (KUU70_00685) | 145589..145816 | - | 228 | WP_003112628.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| KUU70_RS00690 (KUU70_00690) | 145991..146611 | - | 621 | WP_009314940.1 | hypothetical protein | - |
| KUU70_RS00695 (KUU70_00695) | 146719..147219 | + | 501 | WP_003112629.1 | LEA type 2 family protein | - |
| KUU70_RS00700 (KUU70_00700) | 147292..147633 | + | 342 | WP_003101229.1 | zinc ribbon domain-containing protein YjdM | - |
| KUU70_RS00705 (KUU70_00705) | 147715..149142 | - | 1428 | WP_003083784.1 | GABA permease | - |
| KUU70_RS00710 (KUU70_00710) | 149311..150804 | - | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10462.19 Da Isoelectric Point: 10.0435
>T208790 WP_003083773.1 NZ_CP077977:c145592-145311 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T208790 NZ_CP103731:694764-695105 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8568.64 Da Isoelectric Point: 5.5740
>AT208790 WP_003112628.1 NZ_CP077977:c145816-145589 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ
Download Length: 228 bp
>AT208790 NZ_CP103731:694426-694743 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|