208787

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4907919..4908527 Replicon chromosome
Accession NZ_CP077971
Organism Pseudomonas aeruginosa strain ZPPH33

Toxin (Protein)


Gene name PfiT Uniprot ID A0A509JBR4
Locus tag KUU78_RS23120 Protein ID WP_031638390.1
Coordinates 4907919..4908266 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag KUU78_RS23125 Protein ID WP_003114155.1
Coordinates 4908276..4908527 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU78_RS23090 (KUU78_23075) 4903266..4903538 + 273 WP_003120794.1 cysteine-rich CWC family protein -
KUU78_RS23095 (KUU78_23080) 4903538..4904230 + 693 WP_023104853.1 16S rRNA pseudouridine(516) synthase -
KUU78_RS23100 (KUU78_23085) 4904366..4905409 + 1044 WP_003098363.1 L,D-transpeptidase -
KUU78_RS23105 (KUU78_23090) 4905489..4906226 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
KUU78_RS23110 (KUU78_23095) 4906690..4907592 + 903 WP_054376031.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
KUU78_RS23120 (KUU78_23105) 4907919..4908266 - 348 WP_031638390.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUU78_RS23125 (KUU78_23110) 4908276..4908527 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KUU78_RS23130 (KUU78_23115) 4908741..4909724 - 984 WP_034014422.1 tyrosine-type recombinase/integrase -
KUU78_RS23135 (KUU78_23120) 4909724..4911016 - 1293 WP_003123045.1 hypothetical protein -
KUU78_RS23140 (KUU78_23125) 4911275..4912537 - 1263 WP_033953311.1 zonular occludens toxin domain-containing protein -
KUU78_RS23145 (KUU78_23130) 4912539..4912889 - 351 WP_003133726.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4907919..4930125 22206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13018.79 Da        Isoelectric Point: 4.4212

>T208787 WP_031638390.1 NZ_CP077971:c4908266-4907919 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T208787 NZ_CP103729:c5232250-5231867 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT208787 WP_003114155.1 NZ_CP077971:c4908527-4908276 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT208787 NZ_CP103729:c5232492-5232250 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A509JBR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References