Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3648822..3650043 Replicon chromosome
Accession NZ_CP077971
Organism Pseudomonas aeruginosa strain ZPPH33

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KUU78_RS17125 Protein ID WP_003114949.1
Coordinates 3649465..3650043 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KUU78_RS17120 Protein ID WP_003088112.1
Coordinates 3648822..3649376 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU78_RS17095 (KUU78_17085) 3644390..3644941 + 552 WP_003102727.1 XRE family transcriptional regulator -
KUU78_RS17100 (KUU78_17090) 3644938..3645336 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KUU78_RS17105 (KUU78_17095) 3645349..3645672 - 324 WP_003162861.1 multidrug efflux SMR transporter -
KUU78_RS17110 (KUU78_17100) 3646003..3646464 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
KUU78_RS17115 (KUU78_17105) 3646469..3648664 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KUU78_RS17120 (KUU78_17110) 3648822..3649376 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KUU78_RS17125 (KUU78_17115) 3649465..3650043 + 579 WP_003114949.1 HD domain-containing protein Toxin
KUU78_RS17130 (KUU78_17120) 3650151..3651338 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KUU78_RS17135 (KUU78_17125) 3651328..3653499 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
KUU78_RS17140 (KUU78_17130) 3653489..3654766 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T208785 WP_003114949.1 NZ_CP077971:3649465-3650043 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T208785 NZ_CP103729:c4719283-4718999 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT208785 WP_003088112.1 NZ_CP077971:3648822-3649376 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT208785 NZ_CP103729:c4719515-4719273 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References