Detailed information of TA system TA208783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1426472..1427129
• Replicon: chromosome
• Accession: NZ_CP077971
• Organism: Pseudomonas aeruginosa strain ZPPH33

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A8G3IXE4
• Locus tag: KUU78_RS06845
• Protein ID: WP_003098540.1
• Coordinates: 1426947..1427129 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KUU78_RS06840
• Protein ID: WP_034013789.1
• Coordinates: 1426472..1426900 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUU78_RS06805 (KUU78_06805)	1422359..1423063	+	705	WP_023114604.1	phage regulatory protein/antirepressor Ant	-
KUU78_RS06810 (KUU78_06810)	1423128..1423889	+	762	WP_222822328.1	helix-turn-helix domain-containing protein	-
KUU78_RS06815 (KUU78_06815)	1423886..1424569	+	684	WP_038819788.1	replication protein P	-
KUU78_RS06820 (KUU78_06820)	1424566..1424772	+	207	WP_003159465.1	hypothetical protein	-
KUU78_RS06825 (KUU78_06825)	1424769..1425350	+	582	WP_021205616.1	recombination protein NinG	-
KUU78_RS06830 (KUU78_06830)	1425434..1425643	+	210	WP_185988403.1	hypothetical protein	-
KUU78_RS06835 (KUU78_06835)	1425681..1426355	+	675	WP_222822329.1	hypothetical protein	-
KUU78_RS06840 (KUU78_06840)	1426472..1426900	-	429	WP_034013789.1	transcriptional regulator	Antitoxin
KUU78_RS06845 (KUU78_06845)	1426947..1427129	-	183	WP_003098540.1	type II toxin-antitoxin system HicA family toxin	Toxin
KUU78_RS06850 (KUU78_06850)	1427330..1427644	+	315	WP_015649339.1	phage holin, lambda family	-
KUU78_RS06855 (KUU78_06855)	1427644..1428261	+	618	WP_172792804.1	glycoside hydrolase family 19 protein	-
KUU78_RS06860 (KUU78_06860)	1428294..1428731	+	438	WP_223716484.1	lysis system i-spanin subunit Rz	-
KUU78_RS06865 (KUU78_06865)	1428728..1429471	+	744	WP_003159066.1	hypothetical protein	-
KUU78_RS06870 (KUU78_06870)	1429603..1430130	+	528	WP_003128031.1	terminase small subunit	-
KUU78_RS06875 (KUU78_06875)	1430102..1432057	+	1956	WP_223716485.1	phage terminase large subunit family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1407596..1449765	42169

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (7-78)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6746.86 Da
• Isoelectric Point: 11.0775

>T208783 WP_003098540.1 NZ_CP077971:c1427129-1426947 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGLK

Nucleotide

• Length: 183 bp

>T208783 NZ_CP103729:4005722-4005940 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATTCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15799.02 Da
• Isoelectric Point: 4.6562

>AT208783 WP_034013789.1 NZ_CP077971:c1426900-1426472 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KVALWNEMIRRDMRKADLCRLLGIAQIQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEVA

Nucleotide

• Length: 429 bp

>AT208783 NZ_CP103729:4005321-4005695 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG