208771

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2953007..2953661 Replicon chromosome
Accession NZ_CP077969
Organism Escherichia coli strain JM83

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag KTJ86_RS14340 Protein ID WP_000244777.1
Coordinates 2953007..2953414 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KTJ86_RS14345 Protein ID WP_000354046.1
Coordinates 2953395..2953661 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ86_RS14320 (2948964) 2948964..2950697 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
KTJ86_RS14325 (2950703) 2950703..2951413 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KTJ86_RS14330 (2951438) 2951438..2952334 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KTJ86_RS14335 (2952446) 2952446..2952967 + 522 WP_001055874.1 flavodoxin FldB -
KTJ86_RS14340 (2953007) 2953007..2953414 - 408 WP_000244777.1 protein YgfX Toxin
KTJ86_RS14345 (2953395) 2953395..2953661 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KTJ86_RS14350 (2953904) 2953904..2954884 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
KTJ86_RS14355 (2955080) 2955080..2955739 - 660 WP_000250274.1 hemolysin III family protein -
KTJ86_RS14360 (2955903) 2955903..2956214 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
KTJ86_RS14365 (2956259) 2956259..2957692 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
KTJ86_RS14370 (2957749) 2957749..2958492 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T208771 WP_000244777.1 NZ_CP077969:c2953414-2953007 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T208771 NZ_CP103727:3896759-3896977 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT208771 WP_000354046.1 NZ_CP077969:c2953661-2953395 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT208771 NZ_CP103727:3896358-3896732 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References