Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 27092..27674 | Replicon | plasmid p6Pmi283-2 |
| Accession | NZ_CP077965 | ||
| Organism | Proteus mirabilis strain 6Pmi283 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | B1VJ82 |
| Locus tag | KPK64_RS19385 | Protein ID | WP_012368903.1 |
| Coordinates | 27378..27674 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | B1VJ81 |
| Locus tag | KPK64_RS19380 | Protein ID | WP_012368902.1 |
| Coordinates | 27092..27376 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KPK64_RS19335 (KPK64_03886) | 22363..22644 | + | 282 | WP_113355595.1 | CopG family transcriptional regulator | - |
| KPK64_RS19340 (KPK64_03887) | 22700..22876 | + | 177 | WP_218211683.1 | hypothetical protein | - |
| KPK64_RS19345 (KPK64_03888) | 23137..23382 | + | 246 | WP_113355596.1 | hypothetical protein | - |
| KPK64_RS19350 (KPK64_03889) | 23382..23711 | + | 330 | WP_113355598.1 | hypothetical protein | - |
| KPK64_RS19355 (KPK64_03890) | 23802..24326 | + | 525 | WP_255346644.1 | restriction endonuclease | - |
| KPK64_RS19360 (KPK64_03891) | 24303..24659 | - | 357 | WP_073546978.1 | DNA distortion polypeptide 3 | - |
| KPK64_RS19365 (KPK64_03892) | 24669..25829 | - | 1161 | WP_113355603.1 | MobP1 family relaxase | - |
| KPK64_RS19370 (KPK64_03893) | 25837..26385 | - | 549 | WP_218211685.1 | DNA distortion polypeptide 1 | - |
| KPK64_RS19375 | 26705..26860 | + | 156 | WP_218211687.1 | hypothetical protein | - |
| KPK64_RS19380 (KPK64_03894) | 27092..27376 | - | 285 | WP_012368902.1 | putative addiction module antidote protein | Antitoxin |
| KPK64_RS19385 (KPK64_03895) | 27378..27674 | - | 297 | WP_012368903.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KPK64_RS19790 (KPK64_03896) | 27794..27928 | - | 135 | WP_012368904.1 | hypothetical protein | - |
| KPK64_RS19390 (KPK64_03897) | 28004..28348 | - | 345 | WP_012368905.1 | hypothetical protein | - |
| KPK64_RS19395 (KPK64_03898) | 28412..28669 | - | 258 | WP_113355607.1 | hypothetical protein | - |
| KPK64_RS19400 (KPK64_03899) | 28674..28856 | - | 183 | WP_012368908.1 | hypothetical protein | - |
| KPK64_RS19405 (KPK64_03900) | 29229..29459 | - | 231 | WP_012368910.1 | transcriptional regulator | - |
| KPK64_RS19410 (KPK64_03901) | 29449..29715 | - | 267 | WP_218211689.1 | hypothetical protein | - |
| KPK64_RS19415 (KPK64_03902) | 29737..30288 | - | 552 | WP_092514124.1 | hypothetical protein | - |
| KPK64_RS19420 (KPK64_03903) | 30358..30564 | - | 207 | WP_012368913.1 | hypothetical protein | - |
| KPK64_RS19425 (KPK64_03904) | 30619..31143 | - | 525 | WP_012368914.1 | J domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..32132 | 32132 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11325.21 Da Isoelectric Point: 10.2910
>T208741 WP_012368903.1 NZ_CP077965:c27674-27378 [Proteus mirabilis]
MIEIRQTEEVKKWLKGLKDKIAKAKILTRIERMKEGNYGDVEPIGDGYSELRIHQGKGYRVYFANRNNEIILLLCGGDKT
TQQADIKKAKQIAKKWGF
MIEIRQTEEVKKWLKGLKDKIAKAKILTRIERMKEGNYGDVEPIGDGYSELRIHQGKGYRVYFANRNNEIILLLCGGDKT
TQQADIKKAKQIAKKWGF
Download Length: 297 bp
>T208741 NZ_CP103718:c3140438-3140187 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10302.61 Da Isoelectric Point: 4.6286
>AT208741 WP_012368902.1 NZ_CP077965:c27376-27092 [Proteus mirabilis]
MKTKPELFDVVDYLEDEEDIQAYLNAALDEDDESYFLAALGNIARARNISQLSKETGMSREGIYKALSGTGNPSFKTISK
ISKALGLKIHFAGA
MKTKPELFDVVDYLEDEEDIQAYLNAALDEDDESYFLAALGNIARARNISQLSKETGMSREGIYKALSGTGNPSFKTISK
ISKALGLKIHFAGA
Download Length: 285 bp
>AT208741 NZ_CP103718:c3140190-3139936 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1I3XCB7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1I3XCJ1 |