Detailed information of TA system TA208736

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1742171..1742970
• Replicon: chromosome
• Accession: NZ_CP077963
• Organism: Proteus mirabilis strain 6Pmi283

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E3RD10
• Locus tag: KPK64_RS08305
• Protein ID: WP_004247966.1
• Coordinates: 1742446..1742970 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: -
• Locus tag: KPK64_RS08300
• Protein ID: WP_196549233.1
• Coordinates: 1742171..1742449 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPK64_RS08275 (KPK64_01653)	1737521..1738603	+	1083	WP_004242680.1	peptide chain release factor 1	-
KPK64_RS08280 (KPK64_01654)	1738603..1739451	+	849	WP_049196457.1	peptide chain release factor N(5)-glutamine methyltransferase	-
KPK64_RS08285 (KPK64_01655)	1739429..1740244	+	816	WP_004242688.1	invasion regulator SirB1	-
KPK64_RS08290 (KPK64_01656)	1740302..1741156	+	855	WP_004242689.1	3-deoxy-8-phosphooctulonate synthase	-
KPK64_RS08295 (KPK64_01657)	1741164..1742093	+	930	WP_004242691.1	TIGR01212 family radical SAM protein	-
KPK64_RS08300 (KPK64_01658)	1742171..1742449	+	279	WP_196549233.1	DUF1778 domain-containing protein	Antitoxin
KPK64_RS08305 (KPK64_01659)	1742446..1742970	+	525	WP_004247966.1	hypothetical protein	Toxin
KPK64_RS08310 (KPK64_01660)	1743051..1744751	-	1701	WP_004247967.1	C4-dicarboxylic acid transporter DauA	-
KPK64_RS08320 (KPK64_01662)	1745715..1746656	+	942	WP_004242695.1	glyoxylate/hydroxypyruvate reductase GhrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (11-87)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19192.12 Da
• Isoelectric Point: 9.3561

>T208736 WP_004247966.1 NZ_CP077963:1742446-1742970 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Nucleotide

• Length: 525 bp

>T208736 NZ_CP103718:2451223-2451918 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACTATTCAGGCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCG
CAGGAATACACATCAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATT
TATCCGCGACATTTTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGC
CAGAATGATTCCGGCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTG
AAACCAATGTGTTGAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10282.85 Da
• Isoelectric Point: 5.1369

>AT208736 WP_196549233.1 NZ_CP077963:1742171-1742449 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNT

Nucleotide

• Length: 279 bp

>AT208736 NZ_CP103718:2450957-2451223 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA