Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 13289..13890 Replicon chromosome
Accession NZ_CP077963
Organism Proteus mirabilis strain 6Pmi283

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag KPK64_RS00060 Protein ID WP_049199790.1
Coordinates 13289..13672 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag KPK64_RS00065 Protein ID WP_004246496.1
Coordinates 13669..13890 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPK64_RS00035 (KPK64_00007) 8353..9840 - 1488 WP_049208367.1 PLP-dependent aminotransferase family protein -
KPK64_RS00040 (KPK64_00008) 9969..10427 + 459 WP_049203077.1 GNAT family N-acetyltransferase -
KPK64_RS00045 (KPK64_00009) 10523..11260 - 738 WP_004249950.1 tetratricopeptide repeat protein -
KPK64_RS00050 (KPK64_00010) 11369..12268 + 900 WP_017826985.1 N-acetylmuramic acid 6-phosphate etherase -
KPK64_RS00055 (KPK64_00012) 12568..12882 - 315 WP_004246498.1 helix-turn-helix transcriptional regulator -
KPK64_RS00060 (KPK64_00013) 13289..13672 - 384 WP_049199790.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KPK64_RS00065 (KPK64_00014) 13669..13890 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KPK64_RS00070 (KPK64_00015) 14112..14975 - 864 WP_004249947.1 YicC/YloC family endoribonuclease -
KPK64_RS00075 (KPK64_00016) 15102..15818 + 717 WP_004249946.1 ribonuclease PH -
KPK64_RS00080 (KPK64_00017) 15900..16544 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
KPK64_RS00085 (KPK64_00018) 16863..17468 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
KPK64_RS00090 (KPK64_00019) 17588..18046 - 459 WP_049194957.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14490.58 Da        Isoelectric Point: 9.4804

>T208735 WP_049199790.1 NZ_CP077963:c13672-13289 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T208735 NZ_CP103718:c2360311-2360162 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT208735 WP_004246496.1 NZ_CP077963:c13890-13669 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT208735 NZ_CP103718:2359940-2360118 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References