Detailed information of TA system TA208734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 37112..37611
• Replicon: plasmid pWHA07
• Accession: NZ_CP077961
• Organism: Mammaliicoccus sciuri strain WHA07

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KTR69_RS15670
• Protein ID: WP_218697500.1
• Coordinates: 37336..37611 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KTR69_RS15665
• Protein ID: WP_218697499.1
• Coordinates: 37112..37339 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTR69_RS15645	32913..34568	-	1656	WP_218697495.1	polysaccharide biosynthesis protein	-
KTR69_RS15650	34795..34983	-	189	WP_218697496.1	hypothetical protein	-
KTR69_RS15655	34997..35359	-	363	WP_218697497.1	hypothetical protein	-
KTR69_RS15940	36583..36660	-	78	WP_231297272.1	putative holin-like toxin	-
KTR69_RS15665	37112..37339	+	228	WP_218697499.1	DUF6290 family protein	Antitoxin
KTR69_RS15670	37336..37611	+	276	WP_218697500.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KTR69_RS15675	37902..38174	-	273	WP_231297268.1	MerR family transcriptional regulator	-
KTR69_RS15680	38262..38582	-	321	WP_218697501.1	hypothetical protein	-
KTR69_RS15685	38600..39358	-	759	WP_218697503.1	SDR family oxidoreductase	-
KTR69_RS15690	39635..40801	-	1167	WP_218697505.1	PIN domain-containing protein	-
KTR69_RS15945	41259..41393	-	135	WP_231297266.1	hypothetical protein	-
KTR69_RS15695	41695..42120	+	426	Protein_36	DUF805 domain-containing protein	-
KTR69_RS15950	42154..42267	+	114	Protein_37	prevent-host-death protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..58992	58992

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10583.45 Da
• Isoelectric Point: 10.8230

>T208734 WP_218697500.1 NZ_CP077961:37336-37611 [Mammaliicoccus sciuri]
MKYTLKISKKTNKTLSKMDTPTRNLLLKWMNKNIHNTDNPRLYGKALQGELSGLWRYRVGKYRIIVEIQDDELVVLAISV
GKRGSIYNKKS

Nucleotide

• Length: 276 bp

>T208734 NZ_CP103718:c2210250-2210143 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8743.84 Da
• Isoelectric Point: 4.0373

>AT208734 WP_218697499.1 NZ_CP077961:37112-37339 [Mammaliicoccus sciuri]
MATITVRVSDEEKAFLEYMSKFLGISLSQVIKEYTLEELEDMYDAKVGDDALKEYRENGEQSLDIDDVMKQWNVK

Nucleotide

• Length: 228 bp

>AT208734 NZ_CP103718:2210303-2210364 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT