Detailed information of TA system TA208732

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1188670..1189420
• Replicon: chromosome
• Accession: NZ_CP077960
• Organism: Mammaliicoccus sciuri strain WHA07

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: KTR69_RS06030
• Protein ID: WP_224658872.1
• Coordinates: 1189274..1189420 (+)
• Length: 49 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A657XLL6
• Locus tag: KTR69_RS06025
• Protein ID: WP_025904800.1
• Coordinates: 1188670..1189269 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTR69_RS06000	1184391..1185152	+	762	WP_049320866.1	acetylglutamate kinase	-
KTR69_RS06005	1185604..1186731	+	1128	WP_048539836.1	tRNA epoxyqueuosine(34) reductase QueG	-
KTR69_RS06010	1186735..1187208	+	474	WP_025904798.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KTR69_RS06015	1187243..1187383	-	141	WP_162841915.1	hypothetical protein	-
KTR69_RS06020	1187470..1188621	+	1152	WP_096791767.1	N-acetylglucosamine-6-phosphate deacetylase	-
KTR69_RS06025	1188670..1189269	+	600	WP_025904800.1	glucosamine-6-phosphate isomerase	Antitoxin
KTR69_RS06030	1189274..1189420	+	147	WP_224658872.1	SAS053 family protein	Toxin
KTR69_RS06035	1189573..1190961	+	1389	WP_096791768.1	class II fumarate hydratase	-
KTR69_RS06040	1191050..1192576	+	1527	WP_218697380.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (134-195)

Sequences

Toxin

Protein

• Length: 49 a.a.
• Molecular weight: 5713.12 Da
• Isoelectric Point: 3.8403

>T208732 WP_224658872.1 NZ_CP077960:1189274-1189420 [Mammaliicoccus sciuri]
VRNLNKNLEEENEMVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Nucleotide

• Length: 147 bp

>T208732 NZ_CP103718:c2031839-2031345 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22291.16 Da
• Isoelectric Point: 4.8551

>AT208732 WP_025904800.1 NZ_CP077960:1188670-1189269 [Mammaliicoccus sciuri]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGVHLEAEQTSFFDELLDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYDQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Nucleotide

• Length: 600 bp

>AT208732 NZ_CP103718:c2032129-2031836 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A657XLL6