Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 955066..955605 Replicon chromosome
Accession NZ_CP077960
Organism Mammaliicoccus sciuri strain WHA07

Toxin (Protein)


Gene name mazF Uniprot ID A0A418JBZ2
Locus tag KTR69_RS04640 Protein ID WP_048540867.1
Coordinates 955234..955605 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A657XHG2
Locus tag KTR69_RS04635 Protein ID WP_025904510.1
Coordinates 955066..955233 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR69_RS04610 950948..951427 + 480 WP_058612364.1 PH domain-containing protein -
KTR69_RS04615 951417..952937 + 1521 WP_218697257.1 PH domain-containing protein -
KTR69_RS04620 952927..953391 + 465 WP_218697259.1 PH domain-containing protein -
KTR69_RS04625 953423..953785 + 363 WP_058591084.1 holo-ACP synthase -
KTR69_RS04630 953833..954981 + 1149 WP_096792044.1 alanine racemase -
KTR69_RS04635 955066..955233 + 168 WP_025904510.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KTR69_RS04640 955234..955605 + 372 WP_048540867.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KTR69_RS04645 955702..956706 + 1005 WP_048540866.1 PP2C family protein-serine/threonine phosphatase -
KTR69_RS04650 956811..957134 + 324 WP_025904513.1 anti-sigma factor antagonist -
KTR69_RS04655 957139..957615 + 477 WP_025904514.1 anti-sigma B factor RsbW -
KTR69_RS04660 957590..958360 + 771 WP_037589755.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13653.83 Da        Isoelectric Point: 9.9193

>T208731 WP_048540867.1 NZ_CP077960:955234-955605 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDIAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T208731 NZ_CP103718:1163427-1163738 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTATACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6136.65 Da        Isoelectric Point: 4.0121

>AT208731 WP_025904510.1 NZ_CP077960:955066-955233 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE

Download         Length: 168 bp

>AT208731 NZ_CP103718:1163735-1164154 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCCGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATCTGACCTACGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGTGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418JBZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A657XHG2

References