Detailed information of TA system TA208725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2023891..2024488
• Replicon: chromosome
• Accession: NZ_CP077941
• Organism: Halomonas profundi strain MT13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KUO20_RS09305
• Protein ID: WP_235039604.1
• Coordinates: 2024219..2024488 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KUO20_RS09300
• Protein ID: WP_235039603.1
• Coordinates: 2023891..2024232 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUO20_RS09270	2019075..2019554	-	480	WP_235039597.1	DUF1456 family protein	-
KUO20_RS09275	2019648..2020070	-	423	WP_235039598.1	tetratricopeptide repeat protein	-
KUO20_RS09280	2020406..2020828	-	423	WP_235039599.1	VOC family protein	-
KUO20_RS09285	2020945..2021370	-	426	WP_235039600.1	VOC family protein	-
KUO20_RS09290	2021526..2022713	+	1188	WP_235039601.1	DEAD/DEAH box helicase	-
KUO20_RS09295	2022769..2023722	-	954	WP_235039602.1	transcription termination factor Rho	-
KUO20_RS09300	2023891..2024232	+	342	WP_235039603.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KUO20_RS09305	2024219..2024488	+	270	WP_235039604.1	type II toxin-antitoxin system YafQ family toxin	Toxin
KUO20_RS09310	2024552..2024893	-	342	WP_235039605.1	transposase	-
KUO20_RS09315	2025075..2025983	-	909	WP_235039606.1	hypothetical protein	-
KUO20_RS09320	2026421..2026861	-	441	WP_235039607.1	YtoQ family protein	-
KUO20_RS09325	2026940..2027704	-	765	WP_235039608.1	precorrin-6A synthase (deacetylating)	-
KUO20_RS09330	2027701..2028504	-	804	WP_235039609.1	precorrin-4 C(11)-methyltransferase	-
KUO20_RS09335	2028501..2028893	-	393	WP_235039610.1	cobalamin biosynthesis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	2022769..2025983	3214

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (23-102)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10165.89 Da
• Isoelectric Point: 8.0583

>T208725 WP_235039604.1 NZ_CP077941:2024219-2024488 [Halomonas profundi]
MLVLEYSAQFKKDFKKIAKMPIPEILEVGDIISKLQRGESLSLKNVDHPLSGNWLGFRDCHIKPDLVLIYRIDNSTLQLA
RIGSHSEVF

Nucleotide

• Length: 270 bp

>T208725 NZ_CP103718:221735-221842 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12243.06 Da
• Isoelectric Point: 6.2134

>AT208725 WP_235039603.1 NZ_CP077941:2023891-2024232 [Halomonas profundi]
MIQLSATMYDIATHSGVVIMKSEMLSTRIDHDTKVAFTNICDDLGLSPSQALKLFARAVINHGGIPFELKARQPNETTAA
AIQELVEGKGQRSKSLDNMLNDLTEGKVVNACP

Nucleotide

• Length: 342 bp

>AT208725 NZ_CP103718:c221686-221623 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT