Detailed information of TA system TA020872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 1207361..1208157
• Replicon: chromosome
• Accession: NC_004556
• Organism: Xylella fastidiosa Temecula1

Toxin (Protein)

• Gene name: VbhT
• Uniprot ID: Q87CQ8
• Locus tag: PD_RS05290
• Protein ID: WP_004088112.1
• Coordinates: 1207361..1207972 (-)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: VbhA
• Uniprot ID: B2I551
• Locus tag: PD_RS05295
• Protein ID: WP_004088114.1
• Coordinates: 1207969..1208157 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PD_RS05250	1202816..1203703	-	888	WP_012382597.1	YdaU family protein	-
PD_RS05255	1203700..1204488	-	789	WP_011097897.1	Bro-N domain-containing protein	-
PD_RS05260	1204485..1205117	-	633	WP_004088094.1	Bro-N domain-containing protein	-
PD_RS11825	1205114..1205398	-	285	WP_004088096.1	hypothetical protein	-
PD_RS05265	1205395..1205643	-	249	WP_011097898.1	hypothetical protein	-
PD_RS05270	1205640..1205828	-	189	WP_004088102.1	hypothetical protein	-
PD_RS12695	1205856..1206047	-	192	WP_004088104.1	hypothetical protein	-
PD_RS05280	1206306..1206551	-	246	WP_004088108.1	hypothetical protein	-
PD_RS05285	1206636..1207310	+	675	WP_012382600.1	helix-turn-helix transcriptional regulator	-
PD_RS05290	1207361..1207972	-	612	WP_004088112.1	Fic/DOC family protein	Toxin
PD_RS05295	1207969..1208157	-	189	WP_004088114.1	antitoxin VbhA family protein	Antitoxin
PD_RS05305	1208549..1209085	+	537	WP_012382601.1	hypothetical protein	-
PD_RS05310	1209082..1209495	+	414	WP_004088056.1	DUF1566 domain-containing protein	-
PD_RS05315	1209492..1209893	+	402	WP_004088054.1	hypothetical protein	-
PD_RS12700	1209890..1210039	+	150	WP_012382602.1	hypothetical protein	-
PD_RS11830	1210125..1210403	+	279	WP_004088050.1	hypothetical protein	-
PD_RS05320	1210426..1210617	+	192	WP_012382603.1	hypothetical protein	-
PD_RS05325	1210638..1210982	+	345	WP_004088346.1	hypothetical protein	-
PD_RS05330	1211022..1211843	+	822	WP_004088345.1	DUF2303 family protein	-
PD_RS05335	1211859..1212785	+	927	WP_004088344.1	phage recombination protein Bet	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1161143..1217907	56764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (55-152)

Antitoxin

• Antitoxin VbhA (10-56)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22832.60 Da
• Isoelectric Point: 5.1271

>T20872 WP_004088112.1 NC_004556:c1207972-1207361 [Xylella fastidiosa Temecula1]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE

Nucleotide

• Length: 612 bp

>T20872 NC_004556:c1207972-1207361 [Xylella fastidiosa Temecula1]
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGGGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGTCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCGATTTTTGTGTGGCCTTGATGCTGAAGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTTCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACCGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGTGGATTGGC
TAGTATCATCCGCGAAGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6837.77 Da
• Isoelectric Point: 4.9859

>AT20872 WP_004088114.1 NC_004556:c1208157-1207969 [Xylella fastidiosa Temecula1]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA

Nucleotide

• Length: 189 bp

>AT20872 NC_004556:c1208157-1207969 [Xylella fastidiosa Temecula1]
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAGGCCGTGGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATTGCATGA

Structures

Toxin

• AlphaFold DB: Q87CQ8

Antitoxin

• AlphaFold DB: B2I551