208719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2239416..2239930 Replicon chromosome
Accession NZ_CP077936
Organism Staphylococcus aureus strain 319

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag KU496_RS11275 Protein ID WP_000581791.1
Coordinates 2239416..2239625 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KU496_RS11280 Protein ID WP_000138934.1
Coordinates 2239637..2239930 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU496_RS11255 (2235305) 2235305..2236375 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
KU496_RS11260 (2236693) 2236693..2237895 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU496_RS11265 (2238056) 2238056..2238739 - 684 Protein_2189 transposase -
KU496_RS11270 (2239151) 2239151..2239288 - 138 WP_000828354.1 Lmo0850 family protein -
KU496_RS11275 (2239416) 2239416..2239625 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
KU496_RS11280 (2239637) 2239637..2239930 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU496_RS11285 (2240096) 2240096..2241580 + 1485 WP_000571560.1 cardiolipin synthase -
KU496_RS11290 (2241608) 2241608..2242255 + 648 WP_001187612.1 HD domain-containing protein -
KU496_RS11295 (2242868) 2242868..2243740 - 873 WP_000725802.1 membrane protein insertase YidC -
KU496_RS11300 (2243826) 2243826..2244467 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T208719 WP_000581791.1 NZ_CP077936:c2239625-2239416 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208719 NZ_CP103714:c4696672-4696388 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT208719 WP_000138934.1 NZ_CP077936:c2239930-2239637 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208719 NZ_CP103714:c4696904-4696662 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References