208708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 845560..846037 Replicon chromosome
Accession NZ_CP077936
Organism Staphylococcus aureus strain 319

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU496_RS04040 Protein ID WP_000052076.1
Coordinates 845560..845748 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU496_RS04045 Protein ID WP_001059690.1
Coordinates 845777..846037 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU496_RS04010 (841513) 841513..842070 + 558 WP_000824491.1 hypothetical protein -
KU496_RS04015 (842411) 842411..843097 + 687 WP_001574556.1 thermonuclease family protein -
KU496_RS04020 (843454) 843454..843654 + 201 WP_001059082.1 cold-shock protein -
KU496_RS04025 (844151) 844151..844369 - 219 WP_000005879.1 hypothetical protein -
KU496_RS04030 (844431) 844431..844715 - 285 WP_001004401.1 hypothetical protein -
KU496_RS04035 (844803) 844803..845372 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
KU496_RS04040 (845560) 845560..845748 - 189 WP_000052076.1 hypothetical protein Toxin
KU496_RS04045 (845777) 845777..846037 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU496_RS04050 (846378) 846378..846581 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU496_RS04055 (846578) 846578..846814 - 237 WP_000368687.1 hypothetical protein -
KU496_RS04060 (847039) 847039..847620 + 582 WP_001140696.1 histidine phosphatase family protein -
KU496_RS04065 (847693) 847693..848310 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
KU496_RS04070 (848466) 848466..848960 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU496_RS04075 (849359) 849359..849781 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
KU496_RS04080 (849929) 849929..850645 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208708 WP_000052076.1 NZ_CP077936:c845748-845560 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208708 NZ_CP103712:59767-59916 [Escherichia coli O25b:H4-ST131]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208708 WP_001059690.1 NZ_CP077936:c846037-845777 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208708 NZ_CP103712:c59719-59663 [Escherichia coli O25b:H4-ST131]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References