Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1665353..1666129 Replicon chromosome
Accession NZ_CP077933
Organism Staphylococcus aureus strain 359

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KU512_RS08465 Protein ID WP_000031108.1
Coordinates 1665353..1665505 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag KU512_RS08470 Protein ID WP_001251224.1
Coordinates 1665530..1666129 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU512_RS08450 (1661316) 1661316..1662137 + 822 WP_000669376.1 RluA family pseudouridine synthase -
KU512_RS08455 (1662600) 1662600..1663985 - 1386 WP_000116224.1 class II fumarate hydratase -
KU512_RS08460 (1664181) 1664181..1664576 - 396 WP_000901021.1 hypothetical protein -
KU512_RS08465 (1665353) 1665353..1665505 - 153 WP_000031108.1 SAS053 family protein Toxin
KU512_RS08470 (1665530) 1665530..1666129 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
KU512_RS08475 (1666288) 1666288..1666758 - 471 WP_050956565.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KU512_RS08480 (1666763) 1666763..1667890 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
KU512_RS08485 (1668041) 1668041..1668763 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KU512_RS08490 (1668756) 1668756..1670213 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T208698 WP_000031108.1 NZ_CP077933:c1665505-1665353 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T208698 NZ_CP103710:2666332-2666439 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT208698 WP_001251224.1 NZ_CP077933:c1666129-1665530 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT208698 NZ_CP103710:c2666275-2666220 [Escherichia coli O25b:H4-ST131]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References