Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 534226..534703 | Replicon | chromosome |
| Accession | NZ_CP077933 | ||
| Organism | Staphylococcus aureus strain 359 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q2G005 |
| Locus tag | KU512_RS02795 | Protein ID | WP_000052078.1 |
| Coordinates | 534226..534414 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | KU512_RS02800 | Protein ID | WP_001059690.1 |
| Coordinates | 534443..534703 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU512_RS02765 (530267) | 530267..530737 | + | 471 | WP_000824472.1 | hypothetical protein | - |
| KU512_RS02770 (531078) | 531078..531764 | + | 687 | WP_001548082.1 | thermonuclease family protein | - |
| KU512_RS02775 (532121) | 532121..532321 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| KU512_RS02780 (532817) | 532817..533035 | - | 219 | WP_000005886.1 | hypothetical protein | - |
| KU512_RS02785 (533097) | 533097..533381 | - | 285 | WP_001004395.1 | hypothetical protein | - |
| KU512_RS02790 (533469) | 533469..534038 | - | 570 | WP_050956526.1 | lipoprotein N-acylation protein LnsA | - |
| KU512_RS02795 (534226) | 534226..534414 | - | 189 | WP_000052078.1 | hypothetical protein | Toxin |
| KU512_RS02800 (534443) | 534443..534703 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| KU512_RS02805 (535044) | 535044..535247 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| KU512_RS02810 (535244) | 535244..535480 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| KU512_RS02815 (535705) | 535705..536286 | + | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| KU512_RS02820 (536359) | 536359..536976 | - | 618 | WP_000255561.1 | LysE/ArgO family amino acid transporter | - |
| KU512_RS02825 (537131) | 537131..537625 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| KU512_RS02830 (538024) | 538024..538446 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| KU512_RS02835 (538594) | 538594..539310 | + | 717 | WP_000150017.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | vWbp | 489266..555317 | 66051 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7172.84 Da Isoelectric Point: 9.9971
>T208691 WP_000052078.1 NZ_CP077933:c534414-534226 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T208691 NZ_CP103710:640506-640820 [Escherichia coli O25b:H4-ST131]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT208691 WP_001059690.1 NZ_CP077933:c534703-534443 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT208691 NZ_CP103710:640817-641233 [Escherichia coli O25b:H4-ST131]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D6HZ40 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |