Detailed information of TA system TA208686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1370617..1371393
• Replicon: chromosome
• Accession: NZ_CP077932
• Organism: Staphylococcus aureus strain 194

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: KU515_RS06760
• Protein ID: WP_000031109.1
• Coordinates: 1370617..1370769 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KU515_RS06765
• Protein ID: WP_001251224.1
• Coordinates: 1370794..1371393 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU515_RS06745 (1366538)	1366538..1367359	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
KU515_RS06750 (1367816)	1367816..1369201	-	1386	WP_000116239.1	class II fumarate hydratase	-
KU515_RS06755 (1369397)	1369397..1369792	-	396	WP_000901019.1	hypothetical protein	-
KU515_RS06760 (1370617)	1370617..1370769	-	153	WP_000031109.1	SAS053 family protein	Toxin
KU515_RS06765 (1370794)	1370794..1371393	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KU515_RS06770 (1371552)	1371552..1372022	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KU515_RS06775 (1372027)	1372027..1373154	-	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
KU515_RS06780 (1373305)	1373305..1374027	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KU515_RS06785 (1374020)	1374020..1375477	-	1458	WP_225798433.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T208686 WP_000031109.1 NZ_CP077932:c1370769-1370617 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T208686 NZ_CP103706:c19729-19349 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT208686 WP_001251224.1 NZ_CP077932:c1371393-1370794 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT208686 NZ_CP103706:c19950-19729 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAACCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACACTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4