Detailed information of TA system TA208682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2654563..2655339
• Replicon: chromosome
• Accession: NZ_CP077931
• Organism: Staphylococcus aureus strain 195

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: KU526_RS13110
• Protein ID: WP_000031109.1
• Coordinates: 2655187..2655339 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KU526_RS13105
• Protein ID: WP_001251224.1
• Coordinates: 2654563..2655162 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU526_RS13085 (2650479)	2650479..2651936	+	1458	WP_225798433.1	ABC transporter permease subunit	-
KU526_RS13090 (2651929)	2651929..2652651	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KU526_RS13095 (2652802)	2652802..2653929	+	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
KU526_RS13100 (2653934)	2653934..2654404	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KU526_RS13105 (2654563)	2654563..2655162	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KU526_RS13110 (2655187)	2655187..2655339	+	153	WP_000031109.1	SAS053 family protein	Toxin
KU526_RS13115 (2656164)	2656164..2656559	+	396	WP_000901019.1	hypothetical protein	-
KU526_RS13120 (2656755)	2656755..2658140	+	1386	WP_000116239.1	class II fumarate hydratase	-
KU526_RS13125 (2658597)	2658597..2659418	-	822	WP_000669377.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T208682 WP_000031109.1 NZ_CP077931:2655187-2655339 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T208682 NZ_CP103704:c4328926-4328753 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT208682 WP_001251224.1 NZ_CP077931:2654563-2655162 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT208682 NZ_CP103704:c4329250-4328954 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: W8U4V4