Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2453037..2453551 Replicon chromosome
Accession NZ_CP077931
Organism Staphylococcus aureus strain 195

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag KU526_RS11940 Protein ID WP_000581795.1
Coordinates 2453342..2453551 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag KU526_RS11935 Protein ID WP_000138930.1
Coordinates 2453037..2453330 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU526_RS11915 (2448563) 2448563..2449204 + 642 WP_000483162.1 thiamine phosphate synthase -
KU526_RS11920 (2449290) 2449290..2450162 + 873 WP_000725802.1 membrane protein insertase YidC -
KU526_RS11925 (2450712) 2450712..2451359 - 648 WP_225798424.1 HD domain-containing protein -
KU526_RS11930 (2451387) 2451387..2452871 - 1485 WP_000571562.1 cardiolipin synthase -
KU526_RS11935 (2453037) 2453037..2453330 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU526_RS11940 (2453342) 2453342..2453551 + 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
KU526_RS11945 (2453679) 2453679..2453816 + 138 WP_000828354.1 Lmo0850 family protein -
KU526_RS11950 (2454080) 2454080..2455282 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU526_RS11955 (2455600) 2455600..2456670 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU526_RS11960 (2456685) 2456685..2458043 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T208676 WP_000581795.1 NZ_CP077931:2453342-2453551 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208676 NZ_CP103704:2678191-2678298 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT208676 WP_000138930.1 NZ_CP077931:2453037-2453330 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208676 NZ_CP103704:c2678144-2678078 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References