Detailed information of TA system TA208673

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 916753..917230
• Replicon: chromosome
• Accession: NZ_CP077931
• Organism: Staphylococcus aureus strain 195

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KU526_RS04380
• Protein ID: WP_000052076.1
• Coordinates: 917042..917230 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: KU526_RS04375
• Protein ID: WP_225798476.1
• Coordinates: 916753..917013 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU526_RS04340 (912147)	912147..912863	-	717	WP_000150033.1	type I 3-dehydroquinate dehydratase	-
KU526_RS04345 (913011)	913011..913433	+	423	WP_000974451.1	organic hydroperoxide resistance protein	-
KU526_RS04350 (913831)	913831..914325	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
KU526_RS04355 (914481)	914481..915098	+	618	WP_000255550.1	LysE/ArgO family amino acid transporter	-
KU526_RS04360 (915171)	915171..915752	-	582	WP_001140696.1	histidine phosphatase family protein	-
KU526_RS04365 (915976)	915976..916212	+	237	WP_000368687.1	hypothetical protein	-
KU526_RS04370 (916209)	916209..916412	-	204	WP_000145160.1	sterile alpha motif-like domain-containing protein	-
KU526_RS04375 (916753)	916753..917013	+	261	WP_225798476.1	hypothetical protein	Antitoxin
KU526_RS04380 (917042)	917042..917230	+	189	WP_000052076.1	hypothetical protein	Toxin
KU526_RS04385 (917418)	917418..917987	+	570	WP_001106662.1	lipoprotein N-acylation protein LnsA	-
KU526_RS04390 (918075)	918075..918347	+	273	WP_001004400.1	hypothetical protein	-
KU526_RS04395 (918420)	918420..918638	+	219	WP_000005884.1	hypothetical protein	-
KU526_RS04400 (919135)	919135..919335	-	201	WP_001059082.1	cold-shock protein	-
KU526_RS04405 (919692)	919692..920378	-	687	WP_001622483.1	thermonuclease family protein	-
KU526_RS04410 (920719)	920719..921240	-	522	WP_000824479.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / sell / sec	913831..995728	81897

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T208673 WP_000052076.1 NZ_CP077931:917042-917230 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208673 NZ_CP103704:2006864-2006967 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9950.13 Da
• Isoelectric Point: 4.0624

>AT208673 WP_225798476.1 NZ_CP077931:916753-917013 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVPFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208673 NZ_CP103704:c2007005-2006734 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A0E0VP18